Necrostatin-7
Modify Date: 2025-08-25 13:01:07
Necrostatin-7 structure
|
Common Name | Necrostatin-7 | ||
|---|---|---|---|---|
| CAS Number | 351062-08-3 | Molecular Weight | 371.412 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 613.4±65.0 °C at 760 mmHg | |
| Molecular Formula | C16H10FN5OS2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 324.8±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Necrostatin-7Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1]. |
| Name | (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one |
|---|---|
| Synonym | More Synonyms |
| Description | Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 613.4±65.0 °C at 760 mmHg |
| Molecular Formula | C16H10FN5OS2 |
| Molecular Weight | 371.412 |
| Flash Point | 324.8±34.3 °C |
| Exact Mass | 371.031067 |
| PSA | 139.27000 |
| LogP | 2.73 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.805 |
| InChIKey | SMJGLNVGTJLIRV-KBEFMPHXSA-N |
| SMILES | N=C1SC(=Cc2cn[nH]c2-c2ccc(F)cc2)C(=O)N1c1nccs1 |
|
~90%
Necrostatin-7 CAS#:351062-08-3 |
| Literature: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES; YUAN, Junying; YUAN, Chengye; DEGTEREV, Alexei Patent: WO2010/75290 A1, 2010 ; Location in patent: Page/Page column 45 ; |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| (5Z)-5-{[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one |
| HMS621M06 |
| necrotatin-7 |
| Necrostatin-7 |
| Nec-7 |
| 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone Nec-7 |
| 4-Thiazolidinone, 5-[[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-, (5Z)- |