phosphoramidon

Modify Date: 2025-08-24 06:49:46

phosphoramidon structure	Common Name	phosphoramidon
	CAS Number	36357-77-4	Molecular Weight	543.50400
	Density	1.48 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₄N₃O₁₀P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of phosphoramidon

Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].

Name	phosphoramidon
Synonym	More Synonyms

Description	Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE) Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin
Target	Microbial Metabolite
In Vitro	Phosphoramidon (1-500 μM; 30 min) inhibits ET-converting enzyme (ECE) activity in a dose-dependent manner in solubilized rabbit lung membranes[5].
In Vivo	Phosphoramidon (0.25 mg/kg per min; i.v.) suppresses the hypertensive effect of big endothelin-1 in rats[4]. Phosphoramidon (1-30 mg/kg; i.v.; once) blocks the pressor activity of porcine big endothelin-1-(1-39) in rats[5]. Animal Model: Male Sprague-Dawley rats[4] Dosage: 0.25 mg/kg per min Administration: Intravenous injection Result: Markedly suppressed the hypertensive effect of big endothelin-1.

Density	1.48 g/cm3
Molecular Formula	C₂₃H₃₄N₃O₁₀P
Molecular Weight	543.50400
Exact Mass	543.19800
PSA	220.48000
LogP	1.01040
Index of Refraction	1.631
InChIKey	ZPHBZEQOLSRPAK-XLCYBJAPSA-N
SMILES	CC(C)CC(NP(=O)(O)OC1OC(C)C(O)C(O)C1O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN6688000

CHEMICAL NAME :: L-Tryptophan, N-(N-(((6-deoxy-alpha-L-mannopyranosyl)oxy)hydroxypho sphinyl)-L-leucyl)-

CAS REGISTRY NUMBER :: 36357-77-4

LAST UPDATED :: 199206

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H34-N3-O10-P

MOLECULAR WEIGHT :: 543.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 26,621,1973

Safety Phrases	22-24/25

Precursor 0
DownStream 2
CAS#:7658-10-8 6-deoxy-L-Talose CAS#:5156-22-9 H-Leu-Trp-OH

Name: Inhibition of collagenase type 4 after 30 mins by fluorescence plate reader
Source: ChEMBL
Target: N/A
External Id: CHEMBL1066257

Name: Inhibition of human somatic ECE1
Source: ChEMBL
Target: Endothelin-converting enzyme 1
External Id: CHEMBL1045249

Name: In vitro inhibition to recombinant human endothelin converting enzyme
Source: ChEMBL
Target: Endothelin-converting enzyme 1
External Id: CHEMBL675442

Name: Inhibition of Pseudomonas aeruginosa LasB elastase using aminobenzoyl-Ala-Gly-Leu-Ala...
Source: ChEMBL
Target: Elastase
External Id: CHEMBL5257279

Name: Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv...
Source: Shanghai Institute of Organic Chemistry
Target: N/A
External Id: PDBbind-Ki for protein-ligand complexes

Name: Selectivity ratio of IC50 NEP/IC50 ECE
Source: ChEMBL
Target: N/A
External Id: CHEMBL848152

Name: Inhibition of human somatic NEP
Source: ChEMBL
Target: Neprilysin
External Id: CHEMBL1045248

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082

Name: Ratio of inhibitory activities against endothelin converting enzyme-1(ECE-1) and neut...
Source: ChEMBL
Target: N/A
External Id: CHEMBL678352

Name: Inhibition of Endothelin-converting enzyme 1 activity at a concentration of 1 uM
Source: ChEMBL
Target: Endothelin-converting enzyme 1
External Id: CHEMBL878272

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PHOSPHORAMIDON SODIUM SALT

yptophan

phophoramidon

eucyl)

PHOSPHORAMIDON

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Product Name: phosphoramidon
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: phosphoramidon
Price: ￥2508.0/5mg
Purity: 98.0%
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Use of phosphoramidon

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phosphoramidon Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Precursor & DownStream

phosphoramidonBioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.