Arimoclomol citrate
Modify Date: 2024-01-10 17:06:25
Arimoclomol citrate structure
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Common Name | Arimoclomol citrate | ||
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| CAS Number | 368860-21-3 | Molecular Weight | 505.90300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H28ClN3O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Arimoclomol citrateArimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. |
| Name | N-[(2R)-2-hydroxy-3-piperidin-1-ylpropoxy]-1-oxidopyridin-1-ium-3-carboximidoyl chloride,2-hydroxypropane-1,2,3-tricarboxylic acid |
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| Synonym | More Synonyms |
| Description | Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. |
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| Related Catalog | |
| Target |
HSP |
| In Vivo | Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1]. Animal Model: Male Wistar rats weighing 240 to 270 g[1] Dosage: 20 mg/kg Administration: Administered intragastrically, for 5 days Result: Had a protective effect against CCK-induced acute pancreatitis. |
| References |
| Molecular Formula | C20H28ClN3O10 |
|---|---|
| Molecular Weight | 505.90300 |
| Exact Mass | 505.14600 |
| PSA | 202.65000 |
| LogP | 0.56830 |
| Arimoclomol citrate [MI] |
| UNII-Q85FFY6179 |
| Arimoclomol citrate |
| 3-Pyridinecarboximidoyl chloride,N-((2R)-2-hydroxy-3-(1-piperidinyl)propoxy)-,1-oxide,2-hydroxy-1,2,3-propanetricarboxylate (1:1) |