β-Amyrenonol

Modify Date: 2024-01-03 10:19:57

β-Amyrenonol structure	Common Name	β-Amyrenonol
	CAS Number	38242-02-3	Molecular Weight	440.701
	Density	1.1±0.1 g/cm3	Boiling Point	524.0±49.0 °C at 760 mmHg
	Molecular Formula	C₃₀H₄₈O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	221.3±22.4 °C

Use of β-Amyrenonol

β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids[1][2].

Name	(4aR,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,2,4a,6a,6b,9,9,12a-octamethyl-1,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,14b-octadecahydropicen-13(2H)-one
Synonym	More Synonyms

Description	β-Amyrenonol (11-Oxo-β-amyrin), an oleanolic-type triterpenoid in licorice roots, is a precursor of Glycyrrhetinic acid. β-Amyrenonol has anti-proliferative and anti-inflammatory activities, and β-Amyrenonol could function as the skeleton for the synthesis of many triterpenoids[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Inflammation/Immunology
In Vitro	β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC50 value of 26.3 µM[1]. β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells[1]. CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol[3].
References	[1]. James Reed, et al. A Translational Synthetic Biology Platform for Rapid Access to Gram-Scale Quantities of Novel Drug-Like Molecules. Metab Eng. 2017 Jul;42:185-193. [2]. Ming Zhu, et al. Boosting 11-oxo-β-amyrin and Glycyrrhetinic Acid Synthesis in Saccharomyces Cerevisiae via Pairing Novel Oxidation and Reduction System From Legume Plants. Metab Eng. 2018 Jan;45:43-50. [3]. Hikaru Seki, et al. Licorice Beta-Amyrin 11-oxidase, a Cytochrome P450 With a Key Role in the Biosynthesis of the Triterpene Sweetener Glycyrrhizin. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14204-9.

Density	1.1±0.1 g/cm3
Boiling Point	524.0±49.0 °C at 760 mmHg
Molecular Formula	C₃₀H₄₈O₂
Molecular Weight	440.701
Flash Point	221.3±22.4 °C
Exact Mass	440.365417
PSA	37.30000
LogP	8.61
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.545

Hazard Codes	Xi

β-Amyrenonol

Olean-12-en-11-one, 3-hydroxy-, (3β)-

b-Amyrenonol

(3β)-3-Hydroxyolean-12-en-11-one

11-oxo-β-amyrin

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: β-Amyrenonol
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Purity: 98.0%
Delivery: 10 Day
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BioBioPha
China
Product Name: β-Amyrenonol
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: β-Amyrenonol
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DC Chemicals Limited
China
Product Name: β-Amyrenonol
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: β-Amyrenonol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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