Tienilic acid
Modify Date: 2025-08-21 13:49:02
Tienilic acid structure
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Common Name | Tienilic acid | ||
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| CAS Number | 40180-04-9 | Molecular Weight | 331.17 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 534.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C13H8Cl2O4S | Melting Point | 148-149ºC | |
| MSDS | Chinese USA | Flash Point | 277.1±30.1 °C | |
Use of Tienilic acidTienilic acid is a uricosuric diuretic. Tienilic acid possesses certain hepatotoxicity[1][3]. |
| Name | tienilic acid |
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| Synonym | More Synonyms |
| Description | Tienilic acid is a uricosuric diuretic. Tienilic acid possesses certain hepatotoxicity[1][3]. |
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| Related Catalog | |
| In Vivo | Tienilic acid (100 mg/lg in rats and mice, 5 mg/kg in pigs and dog; PO and IV; single dosage) is only found in plasma, eliminates by the biliary and the urinary fast, and exhibits small differences in the different species[2]. Tienilic acid (0-480 mg/kg; PO; for 28 days) decreases blood pressure, serum, uric acid hemoglobin, and increased S-GPT; induces unicellular necrosis of small groups of liver cells[3]. Animal Model: Rats, mice, pigs and dogs[2] Dosage: 100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs Administration: PO and IV; single dosage Result: Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species. Animal Model: Female and male Sprague-Dawley rats[3] Dosage: 0, 30, 120 and 480 mg/kg Administration: PO; for 28 days Result: Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells. |
| References |
[3]. Oker-Blom C, et al. Toxicological studies on tienilic acid in rats. Toxicol Lett. 1980;6(2):93-99. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 534.6±50.0 °C at 760 mmHg |
| Melting Point | 148-149ºC |
| Molecular Formula | C13H8Cl2O4S |
| Molecular Weight | 331.17 |
| Flash Point | 277.1±30.1 °C |
| Exact Mass | 329.952026 |
| PSA | 91.84000 |
| LogP | 3.07 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.632 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
| RTECS | AG9300000 |
| HS Code | 2934999090 |
| Precursor 0 | |
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| DownStream 1 | |
![[2,3-Dichloro-4-[(2-thienyl)hydroxymethyl]phenoxy]acetic acid structure](https://image.chemsrc.com/caspic/428/55901-78-5.png)
CAS#:55901-78-5| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| Tienilic acid |
| (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid |
| Tienilico acido |
| (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid |
| Acidum tienilicum |
| TienilicAcid |
| Selacryn |
| acetic acid, [2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]- |
| Diflurex |
| Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid |
| [2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid |
| Acido tienilico |
| Acide tienilique |
| 2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid |
| [2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid |
| [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic acid |
| Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]- |
| Ticrex |
| {[2,3-dichloro-4-(2-thienylcarbonyl)phenyl]oxy}acetic acid |
| Ticrynafen |
| 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid |
| Thienylic acid |
| [2,3-dichloro-4-(thiophen-2-ylcarbonyl)phenoxy]acetic acid |