BCATc Inhibitor 2
Modify Date: 2024-01-04 12:09:29
BCATc Inhibitor 2 structure
|
Common Name | BCATc Inhibitor 2 | ||
|---|---|---|---|---|
| CAS Number | 406191-34-2 | Molecular Weight | 418.77 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H10ClF3N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BCATc Inhibitor 2BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively[1]. |
| Name | 5-Chloro-N'-{[2-(trifluoromethyl)phenyl]sulfonyl}-1-benzofuran-2-carbohydrazide |
|---|---|
| Synonym | More Synonyms |
| Description | BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.2 μM (rBCATc), 0.8 μM (hBCATc), 3.0 μM (rBCATm)[1]. |
| In Vitro | BCATc Inhibitor 2 decreases calcium influx in neuronal cultures with an IC50=4.8±1.2 μM[1]. |
| In Vivo | BCATc Inhibitor 2 also blocks calcium influx into neuronal cells following inhibition of glutamate uptake, and demonstrates neuroprotective efficacy in vivo[1]. Following a 30 mg/kg subcutaneous injection to Lewis rats, BCATc Inhibitor 2 reaches a peak plasma concentration (Cmax) of 8.28 μg/mL at 0.5 h (tmax). The mean plasma exposure (AUC) value is 19.9 μg h/mL, and the mean terminal half-life ranged from 12 to 15 h, indicating favorable PK parameters of BCATc Inhibitor 2[1]. |
| References |
| Molecular Formula | C16H10ClF3N2O4S |
|---|---|
| Molecular Weight | 418.77 |
| 2-Benzofurancarboxylic acid, 5-chloro-, 2-[[2-(trifluoromethyl)phenyl]sulfonyl]hydrazide |
| 5-Chloro-N'-{[2-(trifluoromethyl)phenyl]sulfonyl}-1-benzofuran-2-carbohydrazide |