α-Lipoic acid-NHS
Modify Date: 2024-01-11 12:04:56
α-Lipoic acid-NHS structure
|
Common Name | α-Lipoic acid-NHS | ||
|---|---|---|---|---|
| CAS Number | 40846-94-4 | Molecular Weight | 303.39800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H17NO4S2 | Melting Point | 93.0-97.0°C | |
| MSDS | N/A | Flash Point | N/A | |
Use of α-Lipoic acid-NHSα-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Name | (2,5-dioxopyrrolidin-1-yl) 5-(dithiolan-3-yl)pentanoate |
|---|---|
| Synonym | More Synonyms |
| Description | α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 93.0-97.0°C |
|---|---|
| Molecular Formula | C12H17NO4S2 |
| Molecular Weight | 303.39800 |
| Exact Mass | 303.06000 |
| PSA | 114.28000 |
| LogP | 2.24560 |
| Storage condition | -20°C |
|
~10%
α-Lipoic acid-NHS CAS#:40846-94-4 |
| Literature: Shi, Lei; Jing, Chao; Ma, Wei; Li, Da-Wei; Halls, Jonathan E.; Marken, Frank; Long, Yi-Tao Angewandte Chemie - International Edition, 2013 , vol. 52, # 23 p. 6011 - 6014 Angew. Chem., 2013 , vol. 125, # 23 p. 6127 - 6130,4 |
|
~%
α-Lipoic acid-NHS CAS#:40846-94-4 |
| Literature: Kates, Steven A.; Casale, Ralph A.; Baguisi, Alexander; Beeuwkes III, Reinier Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 505 - 512 |
CAS#:940-69-2
CAS#:1200-22-2| 2,5-Pyrrolidinedione,1-[[5-(1,2-dithiolan-3-yl)-1-oxopentyl]oxy] |
| 1-(5-[1,2]dithiolan-3-ylpentanoyloxy)pyrrolidine-2,5-dione |
| 1-{[5-(1,2-dithiolan-3-yl)pentanoyl]oxy}-2,5-pyrrolidinedione |