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Henan Tianfu Chemical Co., Ltd.
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1200-22-2

1200-22-2 structure

1200-22-2 structure

Name: lipoic acid
Chemical Name: (R)-lipoic acid
CAS Number: 1200-22-2
Molecular Formula: C₈H₁₄O₂S₂
Molecular Weight: 206.326
Catalog: Chemical reagent Organic reagent Aromatic acid
Create Date: 2018-03-17 08:00:00
Modify Date: 2026-07-03 17:40:19
Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

Name	(R)-lipoic acid
Synonyms	(R)-Thioctic Acid (R)-1,2-Dithiolane-3-valeric Acid DL-Thioctic acid DITHIOLANE-3-PENTANOIC ACID Lipoic acid, 10 mM in DMSO 5-(1,2-Dithiolan-3-yl)pentanoic acid Thiogamma (R)-Alpha-Lipoic Acid (R)-(+)-1,2-DITHIOLANE-3-PENTANOIC ACID 1,2-Dithiolane-3-pentanoic acid Tiobec UNII:73Y7P0K73Y 5-[(3R)-dithiolan-3-yl]valeric acid (R)-α-LipoicAcid> (R)-LIPOIC ACID Acid R (+) Alpha lipoic Acid ( D-Form) (R)-LIPOIC ACID (R)-(+)-1,2-Dithiola R-(+)-ALPHA-LIPOIC ACID (R)-6,8-Thioctic acid Byodinoral (R)-alpha-Thioctic Acid 5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid D-lipoic acid (R)-α-Lipoic Acid 1,2-Dithiolane-3-pentanoic acid, (3R) R-A-LIPOIC ACID (D-LIPOIC ACID) (R)-(+)-1,2-Dithiolane-3-pentanoic acid (R)-(+)-a-Lipoic Acid Lipoic acid ((R)-(+)-α-Lipoic acid (R)-(+)-α-L (R)-(+)-α-Lipoic acid Lipoec R-ALPHA-LIPOIC ACID ipoic acid (R)-lipoicaci (R)-(+)-α Lipoic Acid [R-(+)-Thioctic acid Thioctic acid MFCD01631142 1,2-Dithiolane-3-pentanoic acid, (3R)- (9CI) (R)-5-(1,2-Dithiolan-3-yl)pentanoic acid (R)-(+)-Thioctic Acid (R)-(+)-Lipoic acid,(R)-(+)-Thioctic acid,(R)-(+)- 1,2-Dithiolane-3-pentanoic acid Tiobe (R)-1,2-Dithiolane-3-valeric Acid Thioctic Acid Impurity 19 R-(+)-Alpha-Lipoic Acid 1-2 (3R)-1,2-Dithiolane-3-pentanoic Acid (+)-α-Lipoic acid 5-[(3R)-dithiolan-3-yl]pentanoic acid LIPOIC ACID (D-LIPOIC ACID) 1,2-Dithiolane-3-pentanoic acid, (R) (R)-Thioctic Acid (±)-1,2-Dithiolane-3-valeric acid (R)-6,8-Dithiooctanoic acid 6,8-Dihydrothioctic acid

Description	Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Mitochondrial Metabolism Natural Products >> Acids and Aldehydes Research Areas >> Inflammation/Immunology
Target	Human Endogenous Metabolite
In Vitro	Lipoic acid ((R)-(+)-α-Lipoic acid) is the form biosynthesized in humans which is essential for aerobic metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) is the nutritionally and therapeutically preferred form due to its "vitamin-like" role in metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) and S-(-)-α-Lipoic acid) constitute the racemic mixture Lipoic acid. Only the Lipoic acid ((R)-(+)-α-Lipoic acid) exists in nature and is an essential cofactor of four mitochondrial enzyme complexes. Lipoic acid ((R)-(+)-α-Lipoic acid) has been suggested to be nutritionally and therapeutically preferred form as antioxidant[1].
References	[1]. Nasole E, et al. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.

Density	1.2±0.1 g/cm3
Boiling Point	362.5±11.0 °C at 760 mmHg
Melting Point	46-49ºC
Molecular Formula	C₈H₁₄O₂S₂
Molecular Weight	206.326
Flash Point	173.0±19.3 °C
Exact Mass	206.043518
PSA	87.90000
LogP	2.16
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.562
Storage condition	-20°C Freezer

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

Precursor 9
99427-00-6 104726-74-1 1225192-30-2 1225192-32-4
1225192-34-6 1225192-38-0 1225192-41-5 1225192-43-7
1225192-45-9
DownStream 2
129706-46-3 119365-69-4

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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