lipoic acid

Modify Date: 2024-01-02 10:21:06

lipoic acid Structure
lipoic acid structure
Common Name lipoic acid
CAS Number 1200-22-2 Molecular Weight 206.326
Density 1.2±0.1 g/cm3 Boiling Point 362.5±11.0 °C at 760 mmHg
Molecular Formula C8H14O2S2 Melting Point 46-49ºC
MSDS Chinese USA Flash Point 173.0±19.3 °C

 Use of lipoic acid


Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.

 Names

Name (R)-lipoic acid
Synonym More Synonyms

 lipoic acid Biological Activity

Description Lipoic acid ((R)-(+)-α-Lipoic acid) is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. (R)-(+)-α-Lipoic acid is more effective than racemic Lipoic acid.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Lipoic acid ((R)-(+)-α-Lipoic acid) is the form biosynthesized in humans which is essential for aerobic metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) is the nutritionally and therapeutically preferred form due to its "vitamin-like" role in metabolism. Lipoic acid ((R)-(+)-α-Lipoic acid) and S-(-)-α-Lipoic acid) constitute the racemic mixture Lipoic acid. Only the Lipoic acid ((R)-(+)-α-Lipoic acid) exists in nature and is an essential cofactor of four mitochondrial enzyme complexes. Lipoic acid ((R)-(+)-α-Lipoic acid) has been suggested to be nutritionally and therapeutically preferred form as antioxidant[1].
References

[1]. Nasole E, et al. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 362.5±11.0 °C at 760 mmHg
Melting Point 46-49ºC
Molecular Formula C8H14O2S2
Molecular Weight 206.326
Flash Point 173.0±19.3 °C
Exact Mass 206.043518
PSA 87.90000
LogP 2.16
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.562
Storage condition -20°C Freezer

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes C
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles33

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 Synonyms

Thioctic acid
MFCD01631142
(R)-5-(1,2-Dithiolan-3-yl)pentanoic acid
DL-Thioctic acid
(R)-(+)-1,2-Dithiolane-3-pentanoic acid
5-(1,2-Dithiolan-3-yl)pentanoic acid
(R)-1,2-Dithiolane-3-valeric Acid
(R)-Alpha-Lipoic Acid
1,2-Dithiolane-3-pentanoic acid
5-[(3R)-dithiolan-3-yl]pentanoic acid
(R)-(+)-α-Lipoic acid
(R)-6,8-Thioctic acid
(R)-Thioctic Acid
(±)-1,2-Dithiolane-3-valeric acid
(R)-6,8-Dithiooctanoic acid
6,8-Dihydrothioctic acid
lipoic acid
UNII:73Y7P0K73Y
(R)-α-Lipoic Acid
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