5-Bromouridine

Modify Date: 2024-01-02 10:36:12

5-Bromouridine structure	Common Name	5-Bromouridine
	CAS Number	957-75-5	Molecular Weight	323.10
	Density	2.0±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁BrN₂O₆	Melting Point	180-182 °C (dec.)(lit.)
	MSDS	N/A	Flash Point	N/A

Use of 5-Bromouridine

5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	5-bromouridine
Synonym	More Synonyms

Description	5-Bromouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	2.0±0.1 g/cm3
Melting Point	180-182 °C (dec.)(lit.)
Molecular Formula	C₉H₁₁BrN₂O₆
Molecular Weight	323.10
Exact Mass	321.980042
PSA	124.78000
LogP	-0.92
Index of Refraction	1.691

5-Bromouridine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7300000

CHEMICAL NAME :: Uridine, 5-bromo-

CAS REGISTRY NUMBER :: 957-75-5

BEILSTEIN REFERENCE NO. :: 0033664

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H11-Br-N2-O6

MOLECULAR WEIGHT :: 323.13

WISWESSER LINE NOTATION :: T6NVMVJ EE A- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,205,1980

Hazard Codes	Xn
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	YU7300000

Uridine

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~97%

5-Bromouridine

CAS#:957-75-5

Literature: Kumar; Wiebe; Knaus Canadian Journal of Chemistry, 1994 , vol. 72, # 9 p. 2005 - 2010

5-bromo-2',3',5...

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~85%

5-Bromouridine

CAS#:957-75-5

Literature: Asakura, Jun-ichi; Robins, Morris J. Journal of Organic Chemistry, 1990 , vol. 55, # 16 p. 4928 - 4933

Uridine

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~58%

5-Bromouridine

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5'-O,6-Cyclo-5,...

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uridine triacetate

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5-Bromouridine

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Beta-D-Ribofura...

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5-Bromouridine

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5-Bromocytidine

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5-Bromouridine

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5-hydroxycytidine

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Literature: Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 40, # 9 p. 768 - 775

Precursor 5
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DownStream 7
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