Benzyl-PEG7-alcohol

Modify Date: 2025-09-04 20:38:56

Benzyl-PEG7-alcohol Structure
Benzyl-PEG7-alcohol structure
Common Name Benzyl-PEG7-alcohol
CAS Number 423763-19-3 Molecular Weight 416.50600
Density 1.099±0.06 g/cm3 Boiling Point 508.4±45.0 °C
Molecular Formula C21H36O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Benzyl-PEG7-alcohol


Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-(2-phenylmethoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonym More Synonyms

 Benzyl-PEG7-alcohol Biological Activity

Description Benzyl-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.099±0.06 g/cm3
Boiling Point 508.4±45.0 °C
Molecular Formula C21H36O8
Molecular Weight 416.50600
Exact Mass 416.24100
PSA 84.84000
LogP 1.29510

 Safety Information

HS Code 2909499000

 Synthetic Route

~49%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: James, Kenneth D. Patent: US2008/207505 A1, 2008 ; Location in patent: Page/Page column 32 ;

~99%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

~%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: French, Alister C.; Thompson, Amber L.; Davis, Benjamin G. Angewandte Chemie - International Edition, 2009 , vol. 48, # 7 p. 1248 - 1252

~%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: Pilkington-Miksa, Michael A.; Sarkar, Supti; Writer, Michele J.; Barker, Susie E.; Shamlou, Parviz Ayazi; Hart, Stephen L.; Hailes, Helen C.; Tabor, Alethea B. European Journal of Organic Chemistry, 2008 , # 17 p. 2900 - 2914

~%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

~%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

~%

Benzyl-PEG7-alcohol Structure

Benzyl-PEG7-alcohol

CAS#:423763-19-3

Literature: Burns, Christopher J.; Field, Leslie D.; Morgan, Jacqueline; Petteys, Brian J.; Prashar, Jognandan; Ridley, Damon D.; Sandanayake, K.R.A. Samankumara; Vignevich, Valentina Australian Journal of Chemistry, 2001 , vol. 54, # 7 p. 431 - 438

 Customs

HS Code 2909499000
Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

 Synonyms

1-Phenyl-2,5,8,11,14,17,20-heptaoxadocosan-22-ol
monobenzyl heptaethylene glycol
Heptaethylene glycol Monobenzyl ether
Benzyl-PEG7-alcohol
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