fenbendazole

Modify Date: 2024-01-02 05:37:45

fenbendazole Structure
fenbendazole structure
 Common Name fenbendazole
CAS Number 43210-67-9 Molecular Weight 299.348
Density 1.4±0.1 g/cm3 Boiling Point 541.4±42.0 °C at 760 mmHg
Molecular Formula C15H13N3O2S Melting Point 233°C
MSDS Chinese USA Flash Point 281.2±27.9 °C

 Use of fenbendazole


Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.Target: AntiparasiticFenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the taenia species of tapeworms(It is effective against the Taenia species of tapeworm but not against the common tapeworm, Dipylidium caninum.), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together. Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally. From Wikipedia.

 Names

Name fenbendazole
Synonym More Synonyms

 fenbendazole Biological Activity

Description Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.Target: AntiparasiticFenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites including: giardia, roundworms, hookworms, whipworms, the taenia species of tapeworms(It is effective against the Taenia species of tapeworm but not against the common tapeworm, Dipylidium caninum.), pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides and can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Drug interactions may occur if using bromsalan flukicides such as dibromsalan and tribromsalan. Abortions in cattle and death in sheep have been reported after using these medications together. Fenbendazole is poorly absorbed from the gastrointestinal tract in most species. The LD50 in laboratory animals exceeds 10 g/kg when administered orally. From Wikipedia.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Fenbendazole

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 541.4±42.0 °C at 760 mmHg
Melting Point 233°C
Molecular Formula C15H13N3O2S
Molecular Weight 299.348
Flash Point 281.2±27.9 °C
Exact Mass 299.072845
PSA 92.31000
LogP 4.34
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.679
Storage condition 0-6°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6520500
CHEMICAL NAME :
2-Benzimidazolecarbamic acid, 5-(phenylthio)-, methyl ester
CAS REGISTRY NUMBER :
43210-67-9
LAST UPDATED :
199606
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C15-H13-N3-O2-S
MOLECULAR WEIGHT :
299.37
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 GSR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
42 gm/kg/14D-I
TOXIC EFFECTS :
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Human Cells - not otherwise specified
DOSE/DURATION :
2 mg/L
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS DD6520500
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles4

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Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Epidemiology. Opposite effects of anthelmintic treatment on microbial infection at individual versus population scales.

Science 347(6218) , 175-7, (2015)

Parasitic worms modulate host immune responses in ways that affect microbial co-infections. For this reason, anthelmintic therapy may be a potent tool for indirectly controlling microbial pathogens. H...

Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications.

Vet. J. 181(3) , 241-50, (2009)

Albendazole and fenbendazole are methylcarbamate benzimidazole anthelmintics extensively used to control gastrointestinal parasites in domestic animals. These parent compounds are metabolised to alben...

 Synonyms

Fenbendazole
HOE-881V
Methyl [5-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbamate
Methyl hydrogen [6-(phenylsulfanyl)-1H-benzimidazol-2-yl]carbonimidate
SAFEGARD
MFCD00144301
5-(Phenylthio)-2-benzimidazolecarbamic Acid Methyl Ester
hoe881
fenbendazol
Carbamic acid, N-[6-(phenylthio)-1H-benzimidazol-2-yl]-, methyl ester
EINECS 256-145-7
Febendazole
Fenbedazole
[5-(Phenylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester
Methanol, 1-methoxy-1-[[6-(phenylthio)-1H-benzimidazol-2-yl]imino]-, (E)-
PANACUR
Fenbion
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
Methyl [5-(Phenylthio)benzimidazol-2-yl]carbamate
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Chemsrc provides fenbendazole(CAS#:43210-67-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of fenbendazole are included as well.>> amp version: fenbendazole

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