BC11 hydrobromide

Modify Date: 2024-04-08 14:40:55

BC11 hydrobromide Structure
BC11 hydrobromide structure
Common Name BC11 hydrobromide
CAS Number 443776-49-6 Molecular Weight 290.97
Density N/A Boiling Point N/A
Molecular Formula C8H12BBrN2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BC11 hydrobromide


BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].

 Names

Name {4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)
Synonym More Synonyms

 BC11 hydrobromide Biological Activity

Description BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].
Related Catalog
Target

IC50: 8.2 μM (uPA)[3].

References

[1]. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371.  

[2]. Semina E, et al. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295-310.  

[3]. Longo A, et al. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells. Molecules. 2015 May 28;20(6):9879-89.  

 Chemical & Physical Properties

Molecular Formula C8H12BBrN2O2S
Molecular Weight 290.97
Exact Mass 289.989594

 Synonyms

{4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)
Carbamimidothioic acid, (4-boronophenyl)methyl ester, hydrobromide (1:1)