BC11 hydrobromide

Modify Date: 2024-04-08 14:40:55

BC11 hydrobromide structure	Common Name	BC11 hydrobromide
	CAS Number	443776-49-6	Molecular Weight	290.97
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₁₂BBrN₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BC11 hydrobromide

BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].

Name	{4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)
Synonym	More Synonyms

Description	BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1 Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 8.2 μM (uPA)[3].
References	[1]. Moumbock AFA, et al. BC-11 is a covalent TMPRSS2 fragment inhibitor that impedes SARS-CoV-2 host cell entry. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371. [2]. Semina E, et al. Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching. Eur J Cell Biol. 2016 Sep;95(9):295-310. [3]. Longo A, et al. Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells. Molecules. 2015 May 28;20(6):9879-89.

Molecular Formula	C₈H₁₂BBrN₂O₂S
Molecular Weight	290.97
Exact Mass	289.989594

{4-[(Carbamimidoylsulfanyl)methyl]phenyl}boronic acid hydrobromide (1:1)

Carbamimidothioic acid, (4-boronophenyl)methyl ester, hydrobromide (1:1)

BC11 hydrobromide

Use of BC11 hydrobromide

Names

BC11 hydrobromide Biological Activity

Chemical & Physical Properties

Synonyms