Dopamine D4 receptor antagonist-1
Modify Date: 2025-08-25 10:37:00
Dopamine D4 receptor antagonist-1 structure
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Common Name | Dopamine D4 receptor antagonist-1 | ||
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| CAS Number | 444724-92-9 | Molecular Weight | 326.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H19ClN4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Dopamine D4 receptor antagonist-1Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1]. |
| Name | Dopamine D4 receptor antagonist-1 |
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| Description | Dopamine D4 receptor antagonist-1 is a selective DRD4 antagonists, with a Ki of 9.0 nM for Hd4.2. Dopamine D4 receptor antagonist-1 can be used in study of schizophrenia[1]. |
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| Related Catalog | |
| In Vivo | Dopamine D4 receptor antagonist-1 (10 mg/kg; i.p.; single) shows inhibitory effect on catecholaminergic systems (DOPA accumulation in the hippocampus)[1]. Animal Model: Male Long-Evans rats (180-250 g); knockout of the DA D4 receptor locus mice (D4 KO); wild type rats (WT)[1]. Dosage: 10 mg/kg Administration: Intraperitoneal injection, single. Result: Increased DOPA accumulation in the hippocampus with no effect observed in the striatum. |
| References |
| Molecular Formula | C18H19ClN4 |
|---|---|
| Molecular Weight | 326.82 |
| InChIKey | BRLVOVGBNYPHBQ-UHFFFAOYSA-N |
| SMILES | Clc1cccc(N2CCN(Cc3nc4ccccc4[nH]3)CC2)c1 |