Sigma-1 receptor antagonist 1
Modify Date: 2024-01-17 15:40:55
Sigma-1 receptor antagonist 1 structure
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Common Name | Sigma-1 receptor antagonist 1 | ||
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| CAS Number | 1639220-19-1 | Molecular Weight | 380.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H23Cl2N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Sigma-1 receptor antagonist 1Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain[1]. |
| Name | Sigma-1 receptor antagonist 1 |
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| Description | Sigma‑1 receptor antagonist 1 (compound 137) is a potent and selective sigma-1 receptor (σ1R) antagonist, with a high binding affinity to σ1R receptor (Ki = 1.06 nM). Sigma‑1 receptor antagonist 1 exhibits antineuropathic pain activity and acts as a promising agent for the treatment of neuropathic pain[1]. |
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| Target |
Ki: 1.06 nM (σ1R)[1] |
| In Vitro | Sigma‑1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki = 1.06 nM) and good σ-1/2 selectivity (1344-fold)[1]. |
| In Vivo | Sigma‑1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain[1]. |
| References |
| Molecular Formula | C19H23Cl2N3O |
|---|---|
| Molecular Weight | 380.31 |