prostaglandin D2(PGD2) inhibitor

Modify Date: 2024-01-10 07:01:52

prostaglandin D2(PGD2) inhibitor structure	Common Name	prostaglandin D2(PGD2) inhibitor
	CAS Number	885066-67-1	Molecular Weight	460.353
	Density	1.3±0.1 g/cm3	Boiling Point	682.1±65.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₃Cl₂N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	366.3±34.3 °C

Use of prostaglandin D2(PGD2) inhibitor

PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.

Name	PGD2-IN-1
Synonym	More Synonyms

Description	PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.3 nM[1]
In Vitro	Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonistshave been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically have been shown to inhibit the antigen-induced nasal congestion[1].
References	[1]. Patent: WO/2006/044732A2 [2]. Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.

Benzeneacetic acid, 3-[6-[[2-(2,4-dichlorophenyl)ethyl]amino]-2-methoxy-4-pyrimidinyl]-α,α-dimethyl-

2-[3-(6-{[2-(2,4-Dichlorophenyl)ethyl]amino}-2-methoxy-4-pyrimidinyl)phenyl]-2-methylpropanoic acid

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