3,3'-diiodo-L-thyronine

Modify Date: 2025-08-27 09:53:31

3,3'-diiodo-L-thyronine Structure
3,3'-diiodo-L-thyronine structure
Common Name 3,3'-diiodo-L-thyronine
CAS Number 4604-41-5 Molecular Weight 525.077
Density 2.1±0.1 g/cm3 Boiling Point 520.7±50.0 °C at 760 mmHg
Molecular Formula C15H13I2NO4 Melting Point 178-180ºC
MSDS USA Flash Point 268.7±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 3,3'-diiodo-L-thyronine


3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].

 Names

Name 3,3'-diiodo-L-thyronine
Synonym More Synonyms

 3,3'-diiodo-L-thyronine Biological Activity

Description 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].
Related Catalog
Target

Human Endogenous Metabolite

COX

In Vitro 3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity[2]. 3,3'-Diiodo-L-thyronine of 1 μM has the maximum effect[2]. 3,3'-Diiodo-L-thyronine is produced by further degradation of T3 and rT3[3].
References

[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88.

[2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94.

[3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 520.7±50.0 °C at 760 mmHg
Melting Point 178-180ºC
Molecular Formula C15H13I2NO4
Molecular Weight 525.077
Flash Point 268.7±30.1 °C
Exact Mass 524.893372
PSA 92.78000
LogP 4.55
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.726
Storage condition Amber Vial, -20°C Freezer, Under Inert Atmosphere

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
RIDADR NONH for all modes of transport

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 Synonyms

3,3’-Diiodo-L-thyronine
O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine
3,3'-Diiodo-L-thyronine
L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3-iodo-
EINECS 225-005-7
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