Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,3'-Diiodo-L-thyronine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

4604-41-5

4604-41-5 structure

4604-41-5 structure

Name: 3,3'-diiodo-L-thyronine
Chemical Name: 3,3'-diiodo-L-thyronine
CAS Number: 4604-41-5
Molecular Formula: C₁₅H₁₃I₂NO₄
Molecular Weight: 525.077
Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
Create Date: 2018-08-10 09:08:26
Modify Date: 2026-07-06 13:02:15
3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].

Name	3,3'-diiodo-L-thyronine
Synonyms	3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine 3,3'-Diiodo-L-thyronine (Levothyroxine Impurity) 3,3’-Diiodo-L-thyronine L-Tyrosine,O-(4-hydroxy-3-iodophenyl)-3-iodo 3,3'-L-Diiodothyronine Levothyroxine Impurity 9（Levothyroxine Impurity J） Alanine,3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]-, L- (8CI) EINECS 225-005-7 3'-L-Diiodothyronine (Levothyroxine Impurity J) L-3,3'-Diiodothyronine 3,5-Diiodo-L-tyrosinedihydrae O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine Levothyroxine Imp J 3,3'-L-Diiodothyronine (Levothyroxine Impurity J) O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine //BP 3-[4-(4-Hydroxy-3-iodophenoxy)-3-iodophenyl]-L-alanine O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine O-(4-Hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 3,3'-Diiodo-L-thyronine (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid (2S)-2-azanyl-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propanoic acid Levothyroxine Impurity J (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid LEVOTHYROXINE IMPURITY J \| 3,3-DIIODO-L-THYRONINE (S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenropanoic acid

Description	3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite COX
In Vitro	3,3'-Diiodo-L-thyronine (3,3'-T2; 1 μM; 30 min) significantly enhances COX activity[2]. 3,3'-Diiodo-L-thyronine of 1 μM has the maximum effect[2]. 3,3'-Diiodo-L-thyronine is produced by further degradation of T3 and rT3[3].
References	[1]. Lorenzini L, et al. Assay of Endogenous 3,5-diiodo-L-thyronine (3,5-T2) and 3,3'-diiodo-L-thyronine (3,3'-T2) in Human Serum: A Feasibility Study. Front Endocrinol (Lausanne). 2019 Feb 19;10:88. [2]. Lanni A, et al. Rapid stimulation in vitro of rat liver cytochrome oxidase activity by 3,5-diiodo-L-thyronine and by 3,3'-diiodo-L-thyronine. Mol Cell Endocrinol. 1994 Feb;99(1):89-94. [3]. Chen X, et al. Simultaneous quantification of T4, T3, rT3, 3,5-T2 and 3,3'-T2 in larval zebrafish (Danio rerio) as a model to study exposure to polychlorinated biphenyls. Biomed Chromatogr. 2018 Jun;32(6):e4185.

Density	2.1±0.1 g/cm3
Boiling Point	520.7±50.0 °C at 760 mmHg
Melting Point	178-180ºC
Molecular Formula	C₁₅H₁₃I₂NO₄
Molecular Weight	525.077
Flash Point	268.7±30.1 °C
Exact Mass	524.893372
PSA	92.78000
LogP	4.55
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.726
Storage condition	Amber Vial, -20°C Freezer, Under Inert Atmosphere

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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