2′-O-(2-Methoxyethyl)guanosine

Modify Date: 2024-01-02 19:25:57

2′-O-(2-Methoxyethyl)guanosine structure	Common Name	2′-O-(2-Methoxyethyl)guanosine
	CAS Number	473278-54-5	Molecular Weight	341.32000
	Density	1.811g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₉N₅O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2′-O-(2-Methoxyethyl)guanosine

2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].

Name	2'-O-(2-Methoxyethyl)-guanosine
Synonym	More Synonyms

Description	2′-O-(2-Methoxyethyl)guanosine (2'-O-MOE-rG), a 2′-O-methoxyethyl-modified nucleoside, can be produced by enzymatic conversion (adenosine deaminase) from 2′-O-(2-methoxyethyl)-2,6-diaminopurine riboside. 2′-O-(2-Methoxyethyl)guanosine neither effectively phosphorylated by cytosolic nucleoside kinases, nor are they incorporated into cellular DNA or RNA[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590. [2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. McPherson AK, et, al. An Improved Process for the Manufacture of 5′-O-(4,4′-Dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine. Org. Process Res. Dev. 2020, 24, 11, 2583-2590.

[2]. Saleh AF, et, al. 2'-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells. Toxicol Sci. 2018 May 1;163(1):70-78.

Density	1.811g/cm3
Molecular Formula	C₁₃H₁₉N₅O₆
Molecular Weight	341.32000
Exact Mass	341.13400
PSA	157.74000
Index of Refraction	1.745

Hazard Codes	Xi
HS Code	2909199090

Precursor 5
CAS#:1061667-18-2 2'-methoxyethyl... CAS#:6482-24-2 1-Bromo-2-metho... CAS#:2096-10-8 2-Aminoadenosine CAS#:118-00-3 Guanosine
CAS#:256224-13-2 2-AMINO-2'-O-(2...
DownStream 0

HS Code	2909199090
Summary	2909199090. other acyclic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%