2′-O-methylcytidine

Modify Date: 2025-08-20 22:44:09

2′-O-methylcytidine Structure
2′-O-methylcytidine structure
 Common Name 2′-O-methylcytidine
CAS Number 2140-72-9 Molecular Weight 257.243
Density 1.7±0.1 g/cm3 Boiling Point 506.0±60.0 °C at 760 mmHg
Molecular Formula C10H15N3O5 Melting Point 252-253ºC
MSDS Chinese USA Flash Point 259.8±32.9 °C

 Use of 2′-O-methylcytidine


2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1].

 Names

Name 2'-O-methylcytidine
Synonym More Synonyms

 2′-O-methylcytidine Biological Activity

Description 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate[1].
Related Catalog
References

[1]. Steven S Carroll, et al. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs. J Biol Chem. 2003 Apr 4;278(14):11979-84

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 506.0±60.0 °C at 760 mmHg
Melting Point 252-253ºC
Molecular Formula C10H15N3O5
Molecular Weight 257.243
Flash Point 259.8±32.9 °C
Exact Mass 257.101166
PSA 119.83000
LogP -1.09
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.677
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2'-OMe Cytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one
2'-OMeCytidine
2'-O-Methyl-D-cytidine
2’-O-Methyl Cytidine
O2'-methylcytidine
4-Amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydro-2-furanyl]-2(1H)-pyrimidinone
4-azanyl-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-oxolan-2-yl]pyrimidin-2-one
4-Amino-1-(2-O-methyl-β-D-ribofuranosyl)pyrimidin-2(1H)-on
Cytidine, 2'-O-methyl-
2'-OMe-C
2'-O-methyl-2'-deoxy-cytidine
2′-O-methylcytidine
MFCD00056067
2'-O-Methylcytidine
2&#39-O-Methylcytidine
2'-O-methyl-cytidine
4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-3-methoxy-5-methylol-tetrahydrofuran-2-yl]pyrimidin-2-one
2'-O-(TERT-BUTYLDIMETHYLSILYL)-6A-HYDROXY-7-EPI-PACLITAXEL
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