3,3',4',5,6,7,8-heptamethoxyflavone

Modify Date: 2025-08-25 16:21:18

3,3',4',5,6,7,8-heptamethoxyflavone structure	Common Name	3,3',4',5,6,7,8-heptamethoxyflavone
	CAS Number	1178-24-1	Molecular Weight	432.421
	Density	1.3±0.1 g/cm3	Boiling Point	618.7±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₄O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	268.0±31.5 °C

Use of 3,3',4',5,6,7,8-heptamethoxyflavone

3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].

Name	2-(3,4-dimethoxyphenyl)-3,5,6,7,8-pentamethoxychromen-4-one
Synonym	More Synonyms

Description	3,5,6,7,8,3',4'-heptamethoxyflavone, a flavonoid in C. unshiu peels, exhibits anti-tumor-initiating effect and Anti-neuroinflammatory activity[1][2][3]. 3,5,6,7,8,3',4'-heptamethoxyflavone inhibits collagenase activity and increased type I procollagen content in HDFn cells[1]. 3,5,6,7,8,3',4'-heptamethoxyflavone induces brain-derived neurotrophic factor (BDNF) expression via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells[4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2). [2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9. [3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813. [4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

References

[1]. Kim HI, et al. 3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells. Int J Mol Sci. 2018 Feb 22;19(2).

[2]. Iwase Y, et al. Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants. Cancer Lett. 2001 Feb 10;163(1):7-9.

[3]. Adhikari-Devkota A, et al. Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'. J Food Biochem. 2019 Jun;43(6):e12813.

[4]. Sawamoto A, et al. Citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone induces BDNF via cAMP/ERK/CREB signaling and reduces phosphodiesterase activity in C6 cells. Pharmacol Rep. 2019 Aug;71(4):653-658.

Density	1.3±0.1 g/cm3
Boiling Point	618.7±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₄O₉
Molecular Weight	432.421
Flash Point	268.0±31.5 °C
Exact Mass	432.142029
PSA	94.82000
LogP	1.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.576

HS Code	2914509090

Precursor 10
CAS#:35154-55-3 Natsudaidain CAS#:77-78-1 Dimethyl sulfate CAS#:10496-67-0 2''-HYDROXY-3,4... CAS#:114021-62-4 6'-Hydroxy-3,4,...
CAS#:76650-20-9 (E)-3-(3,4-dime... CAS#:2306-27-6 Sinensetin CAS#:21763-80-4 5-Demethylsinensetin CAS#:683278-67-3 5,8-dihydroxy-6...
CAS#:478-01-3 Nobiletin CAS#:120-14-9 veratraldehyde
DownStream 6
CAS#:2798-20-1 Gardenin B CAS#:19103-54-9 Salvigenin CAS#:21763-80-4 5-Demethylsinensetin CAS#:479-90-3 Artemetin
CAS#:2174-59-6 5-O-Demethylnob... CAS#:1176-88-1 5-OH-HxMF

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%