3,5-DIHYDROXY-7-METHOXYFLAVONE

Modify Date: 2026-07-01 22:45:55

3,5-DIHYDROXY-7-METHOXYFLAVONE Structure
3,5-DIHYDROXY-7-METHOXYFLAVONE structure
Common Name 3,5-DIHYDROXY-7-METHOXYFLAVONE
CAS Number 480-14-8 Molecular Weight 284.26
Density 1.445g/cm3 Boiling Point 512.9ºC at 760 mmHg
Molecular Formula C16H12O5 Melting Point N/A
MSDS N/A Flash Point 195.9ºC

 Use of 3,5-DIHYDROXY-7-METHOXYFLAVONE


Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura[1].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one
Synonym More Synonyms

 3,5-DIHYDROXY-7-METHOXYFLAVONE Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Izalpinin is a dihydrochalcone with cytotoxic effect against cancer cell lines. Izalpinin can be isolated from the leaves of Muntingia calabura[1].
Related Catalog
References

[1]. Chen JJ, et al. Cytotoxic chalcones and flavonoids from the leaves of Muntingia calabura. Planta Med. 2005 Oct;71(10):970-3.  

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.445g/cm3
Boiling Point 512.9ºC at 760 mmHg
Molecular Formula C16H12O5
Molecular Weight 284.26
Flash Point 195.9ºC
Exact Mass 284.06800
PSA 79.90000
LogP 2.87980
Vapour Pressure 2.41E-11mmHg at 25°C
Index of Refraction 1.68
InChIKey PVJNLMXWZXXHSZ-UHFFFAOYSA-N
SMILES COc1cc(O)c2c(=O)c(O)c(-c3ccccc3)oc2c1

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Rao; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1945 , # 22 p. 383,386

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Rao; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1945 , # 22 p. 383,386

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Rao; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1945 , # 22 p. 383,386

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

Learn More
Literature: Rao; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1945 , # 22 p. 383,386

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Brunet, Gunter; Ibrahim, Ragai K. Phytochemistry (Elsevier), 1980 , vol. 19, p. 741 - 746

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Goel; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1958 , # 47 p. 191,193

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

Learn More
Literature: Rao; Seshadri Proceedings - Indian Academy of Sciences, Section A, 1945 , # 22 p. 383,386

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Simpson; Beton Journal of the Chemical Society, 1954 , p. 4065,4067

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3,5-DIHYDROXY-7-METHOXYFLAVONE Structure

3,5-DIHYDROXY-7...

CAS#:480-14-8

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Literature: Simpson; Beton Journal of the Chemical Society, 1954 , p. 4065,4067

 3,5-DIHYDROXY-7-METHOXYFLAVONEBioassay

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This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Cytotoxicity against human KB cells at 20 uM after 72 hrs by neutral red staining
Source: ChEMBL
Target: KB
External Id: CHEMBL2168276
Name: Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamida...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL940524
Name: Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL942481
Name: Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamida...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL940523
Name: Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL942480
Name: Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL942482
Name: Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamida...
Source: ChEMBL
Target: RBL-2H3
External Id: CHEMBL940522
Name: Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL942479
Name: Cytotoxicity against ddY mouse macrophages after 20 hrs by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL940521
Name: Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL942478
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

7-O-Methylgalangin
galangin 3-methyl ether
3,5-dihydroxy-7-methoxyflavone
Isalpinin
Izalpinin
3,5-dihydroxy-7-methoxy-2-phenyl-chromen-4-one
galangin-7-methyl ether

 3,5-DIHYDROXY-7-METHOXYFLAVONE | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: Polar surface area (PSA) of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 79.90000.
Q: What is the English name of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: The English name of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one.
Q: What is the LogP of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: LogP of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 2.87980.
Q: What is the CAS number of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: CAS number of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 480-14-8.
Q: What is the SMILES notation of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: SMILES notation of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is COc1cc(O)c2c(=O)c(O)c(-c3ccccc3)oc2c1.
Q: What is the molecular formula of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: Molecular formula of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is C16H12O5.
Q: What is the Chinese name of 480-14-8?
A: Chinese name of 480-14-8 is 480-14-8.
Q: What is the molecular weight of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: Molecular weight of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 284.26.
Q: What is the boiling point of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one?
A: Boiling point of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one is 512.9ºC at 760 mmHg.
Q: What English synonyms does 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one have?
A: English synonyms of 3,5-dihydroxy-7-methoxy-2-phenylchromen-4-one: 7-O-Methylgalangin, galangin 3-methyl ether, 3,5-dihydroxy-7-methoxyflavone, Isalpinin, Izalpinin, 3,5-dihydroxy-7-methoxy-2-phenyl-chromen-4-one, galangin-7-methyl ether.

 3,5-DIHYDROXY-7-METHOXYFLAVONEfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
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