Formononetin

Modify Date: 2024-01-01 18:34:55

Formononetin Structure
Formononetin structure
 Common Name Formononetin
CAS Number 485-72-3 Molecular Weight 268.264
Density 1.3±0.1 g/cm3 Boiling Point 479.4±45.0 °C at 760 mmHg
Molecular Formula C16H12O4 Melting Point 256-260 °C
MSDS Chinese USA Flash Point 183.4±22.2 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Formononetin


Formononetin (Formononetol; Flavosil) is a bioactive component extracted from the red clover; inhibits the proliferation of DU-145/PC-3 cells in a dose-dependent manner.IC50 value:Target: anti-cancer in vitro: formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax [1]. Formononetin significantly inhibited the cell growth of PC-3 in a dose-dependent manner, but no such effect was observed in RWPE1 cells. Formononetin treatment contributed to the reduced Bcl-2 protein level and the elevated Bax expression in PC-3 cells, thereby resulting in the increasing Bax/Bcl-2 ratios. Furthermore, the phosphorylated level of p38 in PC-3 cells was activated through the FN treatment, whereas the endogenous Akt phosphorylation was blocked [2]. Compared with the control, formononetin inhibited the proliferation of MCF-7 cells and effectively induced cell cycle arrest. The levels of p-IGF-1?R, p-Akt, cyclin D1 protein expression, and cyclin D1 mRNA expression were also downregulated [3].in vivo: formononetin also prevented the tumor growth of human breast cancer cells in nude mouse xenografts [3].

 Names

Name formononetin
Synonym More Synonyms

 Formononetin Biological Activity

Description Formononetin (Formononetol; Flavosil) is a bioactive component extracted from the red clover; inhibits the proliferation of DU-145/PC-3 cells in a dose-dependent manner.IC50 value:Target: anti-cancer in vitro: formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax [1]. Formononetin significantly inhibited the cell growth of PC-3 in a dose-dependent manner, but no such effect was observed in RWPE1 cells. Formononetin treatment contributed to the reduced Bcl-2 protein level and the elevated Bax expression in PC-3 cells, thereby resulting in the increasing Bax/Bcl-2 ratios. Furthermore, the phosphorylated level of p38 in PC-3 cells was activated through the FN treatment, whereas the endogenous Akt phosphorylation was blocked [2]. Compared with the control, formononetin inhibited the proliferation of MCF-7 cells and effectively induced cell cycle arrest. The levels of p-IGF-1?R, p-Akt, cyclin D1 protein expression, and cyclin D1 mRNA expression were also downregulated [3].in vivo: formononetin also prevented the tumor growth of human breast cancer cells in nude mouse xenografts [3].
Related Catalog
References

[1]. Liu XJ, et al. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pac J Cancer Prev. 2014;15(6):2835-9.

[2]. Zhang X, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656-61.

[3]. Chen J, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res. 2011 Sep;43(10):681-6.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 479.4±45.0 °C at 760 mmHg
Melting Point 256-260 °C
Molecular Formula C16H12O4
Molecular Weight 268.264
Flash Point 183.4±22.2 °C
Exact Mass 268.073547
PSA 59.67000
LogP 2.96
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.641
Storage condition Refrigerator

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S37/39-S26-S36
RIDADR NONH for all modes of transport
HS Code 2932999099

 Synthetic Route

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles56

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 Synonyms

4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-
7-hydroxy-4'-methoxy-Isoflavone (8CI)
7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one
Formononetol
4'-O-methyl-daidzein
4H-1-Benzopyran-4-one, 7-hydroxy-3- (4-methoxyphenyl)-
BIOCHANIN B
ForMonentin
BIOCHANIN A
Flavosil
7-Hydroxy-4'-methoxyisoflavone
Neochanin
Myconate
MFCD00016948
BiocaninB
FORMONETIN
7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
EINECS 207-623-9
Formononetin
7-Hydroxy-3-(4-methoxyphenyl)chromone
forMonoetin
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  • Product Name: Formononetin
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  • Purity: 98.0%
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949021-68-5
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