Medicarpin
Modify Date: 2026-07-10 20:36:30
Medicarpin structure
|
Common Name | Medicarpin | ||
|---|---|---|---|---|
| CAS Number | 32383-76-9 | Molecular Weight | 270.280 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 418.8±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H14O4 | Melting Point | 127.5-128.5° | |
| MSDS | N/A | Flash Point | 207.1±28.7 °C | |
Use of MedicarpinMedicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of drugs[1]. |
| Name | (-)-medicarpin |
|---|---|
| Synonym | More Synonyms |
| Description | Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of drugs[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Medicarpin (90 µM; for 48 h) triggers apoptosis in sensitive as well as multidrug resistant P388 cells. P-glycoprotein-expressing P388/DOX cells does not show resistance to medicarpin (IC50≈90 µM for P388 and P388/DOX cells)[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 418.8±45.0 °C at 760 mmHg |
| Melting Point | 127.5-128.5° |
| Molecular Formula | C16H14O4 |
| Molecular Weight | 270.280 |
| Flash Point | 207.1±28.7 °C |
| Exact Mass | 270.089203 |
| PSA | 47.92000 |
| LogP | 2.72 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.630 |
| InChIKey | NSRJSISNDPOJOP-BBRMVZONSA-N |
| SMILES | COc1ccc2c(c1)OC1c3ccc(O)cc3OCC21 |
| Hazard Codes | Xi |
|---|
![(6aS,11aS)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol structure](https://image.chemsrc.com/caspic/314/33983-39-0.png)
| Precursor 7 | |
|---|---|
| DownStream 3 | |
CAS#:1690-62-6|
Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
|
|
Name: Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2399681
|
|
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
|
|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
|
|
Name: Cytotoxicity against mouse RAW264.7 cells by CCK assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL2399680
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
|
|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
|
|
Name: Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ...
Source: ChEMBL
Target: Klebsiella pneumoniae
External Id: CHEMBL4296186
|
|
Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
|
|
Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
|
Total 127, Current Page 1 of 13
1
2
3
4
5
| l-3-Hydroxy-9-methoxypterocarpan |
| UNII-6TX086I6IG |
| (-)-3-Hydroxy-9-methoxypterocarpan |
| 3-hydroxy-9-methoxypterocarpan |
| Demethylhomopterocarpin |
| Medicarpin |
| (6aR-cis)-6a,11a-Dihydro-9-methoxy-6H-benzofuro[3,2-c][1]benzopyran-3-ol |
| (6aR,11aR)-9-Methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol |
| demethylhomopterocarpan |