Baicalein

Modify Date: 2025-08-20 21:52:26

Baicalein Structure
Baicalein structure
 Common Name Baicalein
CAS Number 491-67-8 Molecular Weight 270.237
Density 1.5±0.1 g/cm3 Boiling Point 575.9±50.0 °C at 760 mmHg
Molecular Formula C15H10O5 Melting Point 256-271 °C(lit.)
MSDS Chinese USA Flash Point 225.3±23.6 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Baicalein


Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 mM.

 Names

Name baicalein
Synonym More Synonyms

 Baicalein Biological Activity

Description Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 mM.
Related Catalog
Target

IC50: 3.12 mM (xanthine oxidase)[1]

In Vitro Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Pre-treatment with baicalein significantly suppresses Con A or anti-CD3/CD28 mAb induced proliferation as well as cytokine secretion at 25 μM. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment[2]. Baicalein suppresses proliferation, migration, and invasion of MDA-MB-231 cells in a time- and dose-dependent manner. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes[3].
In Vivo Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo[2]. Rats treated with baicalein are protected against an increase in heart to body weight ratio, plasma level of brain natriuretic peptides, intraventricular septum thickness, myocardial collagen volume of left ventricle (all P<0.05, respectively). The antifibrotic effects of baicalein are further illustrated by the suppressed expression of left ventricle pro-collagens I and III accompanied by the decreased expression of 12-lipoxygenase, and by reduced expression and activity of matrix metallopeptidase 9 and extracellular signal-regulated kinases. Baicalein can inhibit cardiac fibrosis in hypertensive rats[4].
Cell Assay MTT assay is conducted to evaluate the effect of baicalein on proliferation of breast cancer cells. MDA-MB-231 cells are routinely digested, collected, and then seeded in 96-well plates at a density of 8×103 cells/well. After incubation for 12-24 hours, cells are treated with 0, 20, 40, 60, 80, 100, and 120 μM baicalein according to their experimental grouping and then incubated at 37°C for 24, 48, and 72 hours[3].
Animal Admin Rats: Baicalein is suspended in 1% methylcellulose. Rats are treated with baicalein suspension via oral garvage. SHR and WKY rats are divided into 4 groups (n=8 per group): 12-week treatment with high-dose (200 mg/kg/day) or low-dose (50 mg/kg/day) group; and 4-week treatment with high-dose or low-dose group. The 12-week and 4-week negative control groups of SHR and WKY rats (n=8 per group) receive vehicle while positive control groups (Val group, n=8 per group) receive valsartan (20 mg/kg/day) for comparison[4]. Mice: To study the in vivo anti-inflammatory efficacy of baicalein, graft-versus-host disease (GVHD) model is used. Splenic lymphocytes from C57BL/6 mice are incubated with baicalein in vitro (25 μM, 4h) and adoptively transferred to immune-compromised Balb/c mice[2].
References

[1]. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5.

[2]. Patwardhan RS, et al. Baicalein exhibits anti-inflammatory effects via inhibition of NF-κB transactivation. Biochem Pharmacol. 2016 May 15;108:75-89.

[3]. Ma X, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway.Drug Des Devel Ther. 2016 Apr 18;10:1419-41.

[4]. Kong EK, et al. A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensiverats. Eur J Pharmacol. 2011 May 11;658(2-3):175-81.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 575.9±50.0 °C at 760 mmHg
Melting Point 256-271 °C(lit.)
Molecular Formula C15H10O5
Molecular Weight 270.237
Flash Point 225.3±23.6 °C
Exact Mass 270.052826
PSA 90.90000
LogP 3.31
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.732
InChIKey FXNFHKRTJBSTCS-UHFFFAOYSA-N
SMILES O=c1cc(-c2ccccc2)oc2cc(O)c(O)c(O)c12
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles132

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A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

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The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.

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A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performanc...

In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment.

Toxins (Basel.) 6(9) , 2771-86, (2014)

The polyphenolic flavonoid Baicalein has been shown to trigger suicidal death or apoptosis of tumor cells and is thus considered for the prevention and treatment of malignancy. Similar to apoptosis of...

 BaicaleinBioassay

View more

Name: Inhibition of Beta-lactamase at 30 uM by nitrocefin hydrolysis assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1220307
Name: Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL5303714
Name: Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL5303713
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Inhibition of yeast prion protein Sup35 infection of PSI yeast spheroplast cells at 2...
Source: ChEMBL
Target: Eukaryotic peptide chain release factor GTP-binding subunit
External Id: CHEMBL1220301
Name: Inhibition of Beta-lactamase at 30 uM in presence of 0.01% Triton X-100 by nitrocefin...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1220312
Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
Name: Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th...
Source: NCGC
Target: N/A
External Id: s-my-keats_OPM1-m4-1
Name: Induction of cell death in human ZR-75-1 cells at 20 to 50 uM after 24 hrs by WST-1 a...
Source: ChEMBL
Target: ZR-75-1
External Id: CHEMBL3599117
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 Synonyms

4H-1-BENZOPYRAN-4-ONE,5,6,7-TRIHYDROXY-2-PHENYL
Noroxylin
5,6,7-TRIHYDROXYFLAVONE
Baicalein
MFCD00017459
5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one
Baicelein
Baicalin
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