Baicalein-5,6,7-trimethylether

Modify Date: 2024-01-11 00:40:17

Baicalein-5,6,7-trimethylether Structure
Baicalein-5,6,7-trimethylether structure
Common Name Baicalein-5,6,7-trimethylether
CAS Number 973-67-1 Molecular Weight 312.31700
Density 1.242g/cm3 Boiling Point 497.4ºC at 760 mmHg
Molecular Formula C18H16O5 Melting Point 165-167°C
MSDS N/A Flash Point 221.3ºC

 Use of Baicalein-5,6,7-trimethylether


5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].

 Names

Name 5,6,7-trimethoxyflavone
Synonym More Synonyms

 Baicalein-5,6,7-trimethylether Biological Activity

Description 5,6,7-Trimethoxyflavone is a novel p38-α MAPK inhibitor with an anti-inflammatory effect. 5,6,7-Trimethoxyflavone is isolated from several plants including Zeyhera tuberculosa, Callicarpa japonica, and Kickxia lanigera[1].
Related Catalog
Target

p38-α MAPK[1]

References

[1]. Hassan AHE, et al. Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators. Eur J Med Chem. 2019 Jul 9;180:253-267.

 Chemical & Physical Properties

Density 1.242g/cm3
Boiling Point 497.4ºC at 760 mmHg
Melting Point 165-167°C
Molecular Formula C18H16O5
Molecular Weight 312.31700
Flash Point 221.3ºC
Exact Mass 312.10000
PSA 57.90000
LogP 3.48580
Index of Refraction 1.585
Storage condition -20℃

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
HS Code 2914509090

 Synthetic Route

 Customs

HS Code 2914509090
Summary HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Synonyms

5,6,7-trimethoxy-2-phenylchromen-4-one
5,6,7-Trimethoxyflavone
5,6,7-trimethoxy-2-phenyl-4H-chromen-4-one
Baicalein-5,6,7-trimethylether
5,6,7-trimethoxy-2-phenyl-4H-1-benzopyran-4-one
Baicalein Trimethyl Ether
5,6,7-Trimethoxy-2-phenyl-chromen-4-on
MFCD00017457
5,6,7-trimethoxy-2-phenyl-chromen-4-one
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