trans-4-Hydroxycinnamic acid

Modify Date: 2024-01-02 23:22:52

trans-4-Hydroxycinnamic acid Structure
trans-4-Hydroxycinnamic acid structure
Common Name trans-4-Hydroxycinnamic acid
CAS Number 501-98-4 Molecular Weight 164.158
Density 1.3±0.1 g/cm3 Boiling Point 346.1±17.0 °C at 760 mmHg
Molecular Formula C9H8O3 Melting Point 214ºC
MSDS Chinese USA Flash Point 177.3±17.4 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of trans-4-Hydroxycinnamic acid


p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.

 Names

Name p-Coumaric acid
Synonym More Synonyms

 trans-4-Hydroxycinnamic acid Biological Activity

Description p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities.
Related Catalog
References

[1]. Jaganathan SK, et al. Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol. 2013 Nov 21;19(43):7726-34.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 346.1±17.0 °C at 760 mmHg
Melting Point 214ºC
Molecular Formula C9H8O3
Molecular Weight 164.158
Flash Point 177.3±17.4 °C
Exact Mass 164.047348
PSA 57.53000
LogP 1.88
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.660
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD9095000
CHEMICAL NAME :
Cinnamic acid, p-hydroxy-, (E)-
CAS REGISTRY NUMBER :
501-98-4
BEILSTEIN REFERENCE NO. :
2207381
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2850 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 3,675,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1160 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 3,675,1969

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GD9095000
HS Code 2918290000

 Synthetic Route

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trans-4-Hydroxycinnamic acid Structure

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CAS#:501-98-4

Literature: Nakamura, Seikou; Fujimoto, Katsuyoshi; Matsumoto, Takahiro; Nakashima, Souichi; Ohta, Tomoe; Ogawa, Keiko; Matsuda, Hisashi; Yoshikawa, Masayuki Phytochemistry, 2013 , vol. 92, p. 128 - 136

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trans-4-Hydroxycinnamic acid Structure

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CAS#:501-98-4

Literature: Ueda, Minoru; Sawai, Yoshiyuki; Shibazaki, Yuichiro; Tashiro, Chitose; Ohnuki, Takashi; Yamamura, Shosuke Bioscience, Biotechnology and Biochemistry, 1998 , vol. 62, # 11 p. 2133 - 2137

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trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Pirrung, Michael C.; Chen, Jrlung; Rowley, Elizabeth G.; McPhail, Andrew T. Journal of the American Chemical Society, 1993 , vol. 115, # 16 p. 7103 - 7110

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trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Morikawa, Toshio; Pan, Yingni; Ninomiya, Kiyofumi; Imura, Katsuya; Matsuda, Hisashi; Yoshikawa, Masayuki; Yuan, Dan; Muraoka, Osamu Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 5 p. 1882 - 1890

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trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Regos, Ionela; Urbanella, Andrea; Treutter, Dieter Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 13 p. 5843 - 5852

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trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Regos, Ionela; Urbanella, Andrea; Treutter, Dieter Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 13 p. 5843 - 5852

~%

trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Regos, Ionela; Urbanella, Andrea; Treutter, Dieter Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 13 p. 5843 - 5852

~%

trans-4-Hydroxycinnamic acid Structure

trans-4-Hydroxy...

CAS#:501-98-4

Literature: Regos, Ionela; Urbanella, Andrea; Treutter, Dieter Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 13 p. 5843 - 5852

 Customs

HS Code 2918290000
Summary HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

 Articles152

More Articles
Hydroxycinnamic acids used as external acceptors of electrons: an energetic advantage for strictly heterofermentative lactic acid bacteria.

Appl. Environ. Microbiol. 80(24) , 7574-82, (2014)

The metabolism of hydroxycinnamic acids by strictly heterofermentative lactic acid bacteria (19 strains) was investigated as a potential alternative energy route. Lactobacillus curvatus PE5 was the mo...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

Pharm. Biol. 53(6) , 800-6, (2015)

The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

Effect of selected Saccharomyces cerevisiae yeast strains and different aging techniques on the polysaccharide and polyphenolic composition and sensorial characteristics of Cabernet Sauvignon red wines.

J. Sci. Food Agric. 95 , 2132-44, (2015)

The objective of this work was to study the effect of two Saccharomyces cerevisiae yeast strains with different capabilities of polysaccharide liberation during alcoholic fermentation in addition to s...

 Synonyms

4-Hydroxy cinnamic acid
(2E)-3-(4-Hydroxyphenyl)acrylic acid
trans-p-Cumaric Acid
EINECS 231-000-0
3-(4-Hydroxy-phenyl)-acrylic acid
trans-p-Coumaric Acid
2-propenoic acid, 3-(4-hydroxyphenyl)-
E-4-Hydroxycinnamic Acid
(E)-3-(4-Hydroxyphenyl)acrylic acid
2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)-
4-Coumaric acid
trans-4-Hydroxycinnamic Acid
p-Hydroxycinnamic acid,predominantly trans
MFCD00004399
4-Hydroxycinnamic acid
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