procainamide

Modify Date: 2026-07-01 11:11:57

procainamide structure	Common Name	procainamide
	CAS Number	51-06-9	Molecular Weight	235.32500
	Density	1.06	Boiling Point	421.8ºC at 760mmHg
	Molecular Formula	C₁₃H₂₁N₃O	Melting Point	47°C
	MSDS	N/A	Flash Point	208.9ºC

Use of procainamide

Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias[1][2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	procainamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	DNMT1[1]
References	[1]. Lee BH, et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280(49):40749-40756. [2]. Pritchard B, et al. Procainamide. [Updated 2021 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.06
Boiling Point	421.8ºC at 760mmHg
Melting Point	47°C
Molecular Formula	C₁₃H₂₁N₃O
Molecular Weight	235.32500
Flash Point	208.9ºC
Exact Mass	235.16800
PSA	58.36000
LogP	2.31250
Index of Refraction	1.5700 (estimate)
InChIKey	REQCZEXYDRLIBE-UHFFFAOYSA-N
SMILES	CCN(CC)CCNC(=O)c1ccc(N)cc1
Storage condition	2-8°C

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV2275000

CHEMICAL NAME :: Benzamide, p-amino-N-(2-(diethylamino)ethyl)-

CAS REGISTRY NUMBER :: 51-06-9

BEILSTEIN REFERENCE NO. :: 2214285

LAST UPDATED :: 199612

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C13-H21-N3-O

MOLECULAR WEIGHT :: 235.37

WISWESSER LINE NOTATION :: ZR DVM2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 8579 mg/kg/43W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - fibrosing alveolitis

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 76,146,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,340,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1826 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - other changes

REFERENCE :: AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 83,798,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2280 mg/kg/22W

TOXIC EFFECTS :: Musculoskeletal - joints

REFERENCE :: BHJUAV British Heart Journal. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1939- Volume(issue)/page/year: 34,284,1972

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 583 mg/kg/12D-C

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 109,375,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 42,3628,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 33,292,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 54(3),32,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 525 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 42,3628,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 720 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,253,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,833,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,833,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,77,1957 *** REVIEWS *** TOXICOLOGY REVIEW INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4172 No. of Facilities: 66 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 8032 (estimated) No. of Female Employees: 7252 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	T+
RIDADR	2811
Packaging Group	Ⅲ
HS Code	2924299090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

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Literature: JANSSEN PHARMACEUTICA N.V. Patent: WO2006/74984 A1, 2006 ; Location in patent: Page/Page column 42 ; WO 2006/074984 A1

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Literature: Iwaya; Yoshida Shionogi Kenkyusho Nenpo, 1952 , # 2 p. 114 Chem.Abstr., 1957 , p. 10424

2-aminoethyldie...

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2-aminoethyldie...

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4-Nitrobenzoic acid

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2-aminoethyldie...

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Benzocaine

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Literature: Ghielmetti Farmaco, Edizione Scientifica, 1954 , vol. 9, p. 384

N-(2-diethylami...

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Literature: Yamazaki et al. Yakugaku Zasshi, 1953 , vol. 73, p. 294,296 Chem.Abstr., 1954 , p. 2003

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 7
CAS#:1664-52-4 N-(2-(2-DIETHYL... CAS#:614-39-1 ProcainaMide hy... CAS#:122-04-3 4-Nitrobenzoyl ... CAS#:100-36-7 2-aminoethyldie...
CAS#:62-23-7 4-Nitrobenzoic acid CAS#:94-09-7 Benzocaine CAS#:62979-81-1 N-(2-diethylami...
DownStream 1
CAS#:106790-96-9 N-(2-(diethylam...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Partition coefficient (logD6.5)
Source: ChEMBL
Target: N/A
External Id: CHEMBL646647

Name: Effect on ouabain-induced arrhythmias in pentobarbital anesthetized dogs
Source: ChEMBL
Target: Canis lupus familiaris
External Id: CHEMBL667705

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: TP_TRANSPORTER: inhibition of TEA uptake (TEA: 140 uM, Procainamide: 10000 uM) in Xen...
Source: ChEMBL
Target: Solute carrier family 22 member 1
External Id: CHEMBL2077822

Name: pKa (acid-base dissociation constant) as determined by potentiometric titration
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449011

Name: pKa (acid-base dissociation constant) as determined by other workers
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449010

Name: pKa (acid-base dissociation constant) as determined by Luan ref: Pharm. Res. 2005
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449009

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Total 731, Current Page 1 of 74

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

4-Amino-N-(2-diethylaminoethyl)benzamide

4-amino-N-[2-(diethylamino)ethyl]benzamide

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the English name of procainamide?

A: The English name of procainamide is procainamide.

Q: What is the polar surface area (PSA) of procainamide?

A: Polar surface area (PSA) of procainamide is 58.36000.

Q: What is the molecular weight of procainamide?

A: Molecular weight of procainamide is 235.32500.

Q: What is the melting point of procainamide?

A: Melting point of procainamide is 47°C.

Q: What is the molecular formula of procainamide?

A: Molecular formula of procainamide is C13H21N3O.

Q: What are the upstream materials of procainamide?

A: Related upstream materials(CAS) of procainamide: 1664-52-4;614-39-1;122-04-3;100-36-7;62-23-7;94-09-7;62979-81-1.

Q: What is the LogP of procainamide?

A: LogP of procainamide is 2.31250.

Q: What are the downstream products of procainamide?

A: Related downstream products(CAS) of procainamide: 106790-96-9.

Q: What is the CAS number of procainamide?

A: CAS number of procainamide is 51-06-9.

Q: What is the SMILES notation of procainamide?

A: SMILES notation of procainamide is CCN(CC)CCNC(=O)c1ccc(N)cc1.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Procainamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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