4,6-Dioxoheptanoic acid
4,6-Dioxoheptanoic acid structure
|
Common Name | 4,6-Dioxoheptanoic acid | ||
|---|---|---|---|---|
| CAS Number | 51568-18-4 | Molecular Weight | 158.15200 | |
| Density | 1.189 g/cm3 | Boiling Point | 318.7ºC at 760 mmHg | |
| Molecular Formula | C7H10O4 | Melting Point | 66-67ºC | |
| MSDS | Chinese USA | Flash Point | 160.8ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 4,6-Dioxoheptanoic acid4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis. |
| Name | 4,6-dioxoheptanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | 4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | 4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture[1]. |
| References |
| Density | 1.189 g/cm3 |
|---|---|
| Boiling Point | 318.7ºC at 760 mmHg |
| Melting Point | 66-67ºC |
| Molecular Formula | C7H10O4 |
| Molecular Weight | 158.15200 |
| Flash Point | 160.8ºC |
| Exact Mass | 158.05800 |
| PSA | 71.44000 |
| LogP | 0.39940 |
| Index of Refraction | 1.455 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918300090 |
|
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4,6-Dioxoheptan... CAS#:51568-18-4 |
| Literature: Pendarvis,R.O.; Hampton,K.G. Journal of Organic Chemistry, 1974 , vol. 39, p. 2289 - 2291 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2918300090 |
|---|---|
| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation.
Haematologica 100 , 720-9, (2015) Feline leukemia virus subgroup C receptor 1 (Flvcr1) encodes two heme exporters: FLVCR1a, which localizes to the plasma membrane, and FLVCR1b, which localizes to mitochondria. Here, we investigated th... |
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Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
J. Immunol. 195 , 2763-73, (2015) Pulmonary tuberculosis (TB) is characterized by oxidative stress and lung tissue destruction by matrix metalloproteinases (MMPs). The interplay between these distinct pathological processes and the im... |
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Single dose NTBC-treatment of hereditary tyrosinemia type I.
J. Inherit. Metab. Dis. 35(5) , 831-6, (2012) NTBC (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3cyclohexanedione) is the mainstay of treatment in tyrosinemia type 1 (HT 1). The current recommendation is to divide the total daily dose of NTBC into two... |
| 4,6-Dioxoheptanoic acid |
| Succinylacetone |
| 4,6-DIOXOHEPTANOIC ACID |
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- Product Name: 4,6-Dioxoheptanoic acid
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