SID 3712249
Modify Date: 2024-01-09 12:06:24
SID 3712249 structure
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Common Name | SID 3712249 | ||
|---|---|---|---|---|
| CAS Number | 522606-67-3 | Molecular Weight | 323.396 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 669.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H21N7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 358.4±31.5 °C | |
Use of SID 3712249SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. |
| Name | SID 3712249 |
|---|---|
| Synonym | More Synonyms |
| Description | SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). Target: MiR-544MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 669.0±55.0 °C at 760 mmHg |
| Molecular Formula | C17H21N7 |
| Molecular Weight | 323.396 |
| Flash Point | 358.4±31.5 °C |
| Exact Mass | 323.185852 |
| LogP | 2.27 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.731 |
| Storage condition | 2-8℃ |
| RIDADR | NONH for all modes of transport |
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| 1,8-Diamino-3,6-di(pyrrolidin-1-yl)-2,7-naphthyridine-4-carbonitrile |
| MFCD03483890 |
| 1,8-Diamino-3,6-di(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile |
| 2,7-Naphthyridine-4-carbonitrile, 1,8-diamino-3,6-di-1-pyrrolidinyl- |