Phloretin

Modify Date: 2026-07-02 08:48:01

Phloretin Structure
Phloretin structure
 Common Name Phloretin
CAS Number 60-82-2 Molecular Weight 274.269
Density 1.4±0.1 g/cm3 Boiling Point 534.4±29.0 °C at 760 mmHg
Molecular Formula C15H14O5 Melting Point ~260 °C
MSDS Chinese USA Flash Point 291.1±20.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Phloretin


Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name phloretin
Synonym More Synonyms

 Phloretin Biological Activity

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description Phloretin(NSC 407292; RJC 02792) is a dihydrochalcone, a type of natural phenols. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2.IC50 Value: 49 +/- 12 microM [4]Target: SGLT1/2in vitro: Phlorizin blocks glucose transport across the renal tubule at concentrations in renal blood and tissue in the range of 10-5 to 10-7 M [1]. PT significantly enhanced glycerol release and inhibited the adipogenesis-related transcription factors. PT also promoted phosphorylation of AMP-activated protein kinase and increased activity of adipose triglyceride lipase and hormone-sensitive lipase in 3T3-L1 cells [2]. Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased [3]. D-glucose-transport activity was observed with a Km for D-glucose of 3.4 +/- 0.2 mM (mean +/- S.E.M.) and was inhibited by cytochalasin B (IC50= 0.44 +/- 0.03 microM), HgCl2 (IC50)= 3.5 +/- 0.5 microM), phloretin (IC50= 49 +/- 12 microM) and phloridzin (IC50= 355 +/- 67 microM) [4].in vivo: The effect of phloridzin orally doses 5, 10, 20 and 40 mg/kg body weight on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1. From beneficial effect of this compound is significant reduction of blood glucose levels and improve dyslipidemia in diabetic rats [5].
Related Catalog
References

[1]. CHAN SS, LOTSPEICH WD. Comparative effects of phlorizin and phloretin on glucose transport in the cat kidney. Am J Physiol. 1962 Dec;203:975-9.

[2]. Huang WC, Chang WT, Wu SJ, Phloretin and phlorizin promote lipolysis and inhibit inflammation in mouse 3T3-L1 cells and in macrophage-adipocyte co-cultures. Mol Nutr Food Res. 2013 Jun 17.

[3]. Luo H, Wang YJ, Chen J, Phloretin induces apoptosis of BEL-7402 cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul;28(7):1249-51.

[4]. Kasahara T, Kasahara M. Expression of the rat GLUT1 glucose transporter in the yeast Saccharomyces cerevisiae. Biochem J. 1996 Apr 1;315 ( Pt 1):177-82.

[5]. Najafian M, Jahromi MZ, Nowroznejhad MJ, Phloridzin reduces blood glucose levels and improves lipids metabolism in streptozotocin-induced diabetic rats. Mol Biol Rep. 2012 May;39(5):5299-306.

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.4±0.1 g/cm3
Boiling Point 534.4±29.0 °C at 760 mmHg
Melting Point ~260 °C
Molecular Formula C15H14O5
Molecular Weight 274.269
Flash Point 291.1±20.8 °C
Exact Mass 274.084137
PSA 97.99000
LogP 3.50
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.685
InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N
SMILES O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O
Storage condition 2-8°C
Water Solubility soluble

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2942000000

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2914501900
Summary 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Articles94

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression.

Oncotarget 6 , 37281-99, (2015)

Melanoma is a largely incurable skin malignancy owing to the underlying molecular and metabolic heterogeneity confounded by the development of resistance. Cancer cells have metabolic flexibility in ch...

Antagonistic control of a dual-input mammalian gene switch by food additives.

Nucleic Acids Res. 42(14) , e116, (2014)

Synthetic biology has significantly advanced the design of mammalian trigger-inducible transgene-control devices that are able to programme complex cellular behaviour. Fruit-based benzoate derivatives...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

 PhloretinBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 13...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943200
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 14...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943199
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 11...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943202
Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 12...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943201
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 9 ...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943204
Name: Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 10...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL1943203
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
Total 617, Current Page 1 of 62
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

QR CQ EQ BV2R DQ
Dihydronaringenin
2',4',6',4-tetrahydroxydihydrochalcone
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone
β-(p-Hydroxyphenyl)phloropropiophenone
phloretol
4,2',4',6'-tetrahydroxydihydrochalcone
b-(p-Hydroxyphenyl)phloropropiophenone
UNII-S5J5OE47MK
3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
EINECS 200-488-7
Phloretin
MFCD00002288

 Phloretin | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does phloretin have?
A: English synonyms of phloretin: QR CQ EQ BV2R DQ, Dihydronaringenin, 2',4',6',4-tetrahydroxydihydrochalcone, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone, β-(p-Hydroxyphenyl)phloropropiophenone, phloretol, 4,2',4',6'-tetrahydroxydihydrochalcone, b-(p-Hydroxyphenyl)phloropropiophenone, UNII-S5J5OE47MK, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one, EINECS 200-488-7, Phloretin, MFCD00002288.
Q: What is the safety information for phloretin?
A: Safety information for phloretin: S37/39-S26.
Q: What is the English name of phloretin?
A: The English name of phloretin is phloretin.
Q: What is the polar surface area (PSA) of phloretin?
A: Polar surface area (PSA) of phloretin is 97.99000.
Q: How is the water solubility of phloretin?
A: Water solubility of phloretin: soluble.
Q: What is the CAS number of phloretin?
A: CAS number of phloretin is 60-82-2.
Q: What are the storage conditions for phloretin?
A: Storage conditions for phloretin: 2-8°C.
Q: What is the boiling point of phloretin?
A: Boiling point of phloretin is 534.4±29.0 °C at 760 mmHg.
Q: What is the molecular weight of phloretin?
A: Molecular weight of phloretin is 274.269.
Q: What is the SMILES notation of phloretin?
A: SMILES notation of phloretin is O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O.

 Phloretinfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
BioBioPha
Dayang Chem (Hangzhou) Co., Ltd.
naturewill
Henan Tianfu Chemical Co., Ltd.
Zhongshan Xingrui Chemical Co. , Ltd.
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Chemsrc provides Phloretin(CAS#:60-82-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Phloretin are included as well.>> amp version: Phloretin

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