Coenzyme A
Coenzyme A structure
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Common Name | Coenzyme A | ||
|---|---|---|---|---|
| CAS Number | 85-61-0 | Molecular Weight | 767.534 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 146 - 147 | |
| Molecular Formula | C21H36N7O16P3S | Melting Point | -5ºC | |
| MSDS | N/A | Flash Point | N/A | |
Use of Coenzyme ACoenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. |
Summary: Coenzyme A (Chinese name: 辅酶A, CAS number: 85-61-0) is an important coenzyme with a molecular formula of C21H36N7O16P3S and a molecular weight of 767.534. It appears as a transparent golden liquid with a foul odor, with a melting point of -5°C and a boiling point of 146-147°C. Its density is 2.0±0.1 g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | coenzyme A |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 146 - 147 |
| Melting Point | -5ºC |
| Molecular Formula | C21H36N7O16P3S |
| Molecular Weight | 767.534 |
| Exact Mass | 767.115234 |
| PSA | 414.79000 |
| LogP | -4.02 |
| Index of Refraction | 1.737 |
| InChIKey | RGJOEKWQDUBAIZ-LMNWYZMXSA-N |
| SMILES | CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS |
| Storage condition | −20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Safety Phrases | S24/25 |
|---|---|
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
|---|---|
| DownStream 8 | |
CAS#:52-90-4
CAS#:79-83-4
CAS#:56-65-5
CAS#:70-18-8
CAS#:31664-36-5
CAS#:6477-52-7
CAS#:1264-52-4
CAS#:1763-10-6
CAS#:56-40-6
CAS#:51146-56-6
CAS#:1926-57-4
CAS#:2140-48-9
CAS#:61-19-8This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Coalip |
| COA-SH |
| coenzyme-A |
| EINECS 201-619-0 |
| CoASH |
| Lucina |
| [(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate |
| CoA |
| Thiol-CoA |
| co-enzyme-A |
| MFCD06795839 |
| HSCoA |
| HS-CoA |
| CONENZYME A |
| Coenzyme A |
| Aluzime |
| Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate) |
| Coenzym A |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of coenzyme A? |
| A: The English name of coenzyme A is coenzyme A. |
| Q: What is the polar surface area (PSA) of coenzyme A? |
| A: Polar surface area (PSA) of coenzyme A is 414.79000. |
| Q: What are the storage conditions for coenzyme A? |
| A: Storage conditions for coenzyme A: −20°C. |
| Q: What is the boiling point of coenzyme A? |
| A: Boiling point of coenzyme A is 146 - 147. |
| Q: What is the molecular formula of coenzyme A? |
| A: Molecular formula of coenzyme A is C21H36N7O16P3S. |
| Q: What are the downstream products of coenzyme A? |
| A: Related downstream products(CAS) of coenzyme A: 51146-56-6;1926-57-4;2140-48-9;61-19-8;70-18-8;6477-52-7;31664-36-5;79-83-4. |
| Q: What are the upstream materials of coenzyme A? |
| A: Related upstream materials(CAS) of coenzyme A: 52-90-4;79-83-4;56-65-5;70-18-8;31664-36-5;6477-52-7;1264-52-4;1763-10-6;56-40-6. |
| Q: What is the melting point of coenzyme A? |
| A: Melting point of coenzyme A is -5ºC. |
| Q: What is the InChIKey of coenzyme A? |
| A: InChIKey of coenzyme A is RGJOEKWQDUBAIZ-LMNWYZMXSA-N. |
| Q: What is the SMILES notation of coenzyme A? |
| A: SMILES notation of coenzyme A is CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |