Coenzyme A

Modify Date: 2024-01-02 22:42:13

Coenzyme A structure	Common Name	Coenzyme A
	CAS Number	85-61-0	Molecular Weight	767.534
	Density	2.0±0.1 g/cm3	Boiling Point	146 - 147
	Molecular Formula	C₂₁H₃₆N₇O₁₆P₃S	Melting Point	-5ºC
	MSDS	N/A	Flash Point	N/A

Use of Coenzyme A

Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1].

Name	coenzyme A
Synonym	More Synonyms

Description	Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Baković J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2.

Density	2.0±0.1 g/cm3
Boiling Point	146 - 147
Melting Point	-5ºC
Molecular Formula	C₂₁H₃₆N₇O₁₆P₃S
Molecular Weight	767.534
Exact Mass	767.115234
PSA	414.79000
LogP	-4.02
Index of Refraction	1.737
Storage condition	−20°C

Coenzyme A MSDS(Chinese)

Safety Phrases	S24/25
WGK Germany	3

Precursor 9
CAS#:52-90-4 L-cysteine CAS#:79-83-4 D-Pantothenic acid CAS#:56-65-5 Adenosine triph... CAS#:70-18-8 Glutathione
CAS#:31664-36-5 CoenzymeA, oxid... CAS#:6477-52-7 CoA-glutathione CAS#:1264-52-4 Octanoyl Coenzyme A CAS#:1763-10-6 Palmitoyl coenzyme A
CAS#:56-40-6 Glycine
DownStream 8
CAS#:51146-56-6 (S)-(+)-Ibuprofen CAS#:1926-57-4 Lactyl-CoA CAS#:2140-48-9 butyryl-CoA CAS#:61-19-8 5'-Adenylic acid
CAS#:70-18-8 Glutathione CAS#:6477-52-7 CoA-glutathione CAS#:31664-36-5 CoenzymeA, oxid... CAS#:79-83-4 D-Pantothenic acid

Coalip

COA-SH

coenzyme-A

EINECS 201-619-0

CoASH

Lucina

[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-({3-oxo-3-[(2-sulfanylethyl)amino]propyl}amino)butyl dihydrogen diphosphate

CoA

Thiol-CoA

co-enzyme-A

MFCD06795839

HSCoA

HS-CoA

CONENZYME A

Coenzyme A

Aluzime

Adenosine, 5'-O-[hydroxy[[hydroxy[(3R)-3-hydroxy-4-[[3-[(2-mercaptoethyl)amino]-3-oxopropyl]amino]-2,2-dimethyl-4-oxobutoxy]phosphinyl]oxy]phosphinyl]-, 3'-(dihydrogen phosphate)

Coenzym A