Sesamolin

Modify Date: 2025-08-26 22:21:16

Sesamolin structure	Common Name	Sesamolin
	CAS Number	526-07-8	Molecular Weight	370.353
	Density	1.4±0.1 g/cm3	Boiling Point	520.8±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₈O₇	Melting Point	93 - 94ºC (Decomposes)
	MSDS	N/A	Flash Point	219.2±30.0 °C

Use of Sesamolin

Sesaminol, isolated from Justicia orbiculata, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression[1][2][3][4].

Name	sesamolin
Synonym	More Synonyms

Description	Sesaminol, isolated from Justicia orbiculata, has antioxidative activity, Sesaminol inhibits lipid peroxidation and shows neuroprotection effect. Sesaminol potently inhibits MAPK cascades by preventing phosphorylation of JNK, p38 MAPKs, and caspase-3 but not ERK-MAPK expression[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Metabolic Disease Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> JNK
References	[1]. Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139. [2]. Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022. [3]. Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. [4]. Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97(1):85-95.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Caspase

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Metabolic Disease

Research Areas >> Neurological Disease

Signaling Pathways >> MAPK/ERK Pathway >> JNK

References

[1]. Dorothea Bedigian, et al. Sesamin, sesamolin and the origin of sesame. Biochemical Systematics and Ecology. Volume 13, Issue 2, 23 May 1985, Pages 133-139.

[2]. Myung-Hwa Kang, et al. Sesamolin Inhibits Lipid Peroxidation in Rat Liver and Kidney. The Journal of Nutrition, Volume 128, Issue 6, June 1998, Pages 1018–1022.

[3]. Rolis Chien‐Wei Hou, et al. Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells.

[4]. Lim JS, et al. Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats. Br J Nutr. 2007 Jan;97(1):85-95.

Density	1.4±0.1 g/cm3
Boiling Point	520.8±50.0 °C at 760 mmHg
Melting Point	93 - 94ºC (Decomposes)
Molecular Formula	C₂₀H₁₈O₇
Molecular Weight	370.353
Flash Point	219.2±30.0 °C
Exact Mass	370.105255
PSA	64.61000
LogP	2.88
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.622
InChIKey	ZZMNWJVJUKMZJY-AFHBHXEDSA-N
SMILES	c1cc2c(cc1OC1OCC3C(c4ccc5c(c4)OCO5)OCC13)OCO2

Hazard Codes	Xi
WGK Germany	3.0
HS Code	29329990

Name: Inhibition of rat intestinal sucrase using sucrose as substrate at 10 mg/ml preincuba...
Source: ChEMBL
Target: Sucrase-isomaltase, intestinal
External Id: CHEMBL2061354

Name: Inhibition of Wnt/beta-catenin signaling pathway in human HEK293 cells at 20 uM after...
Source: ChEMBL
Target: HEK293
External Id: CHEMBL2445921

Name: Inhibition of rat intestinal maltase using maltose as substrate at 10 mg/ml preincuba...
Source: ChEMBL
Target: Lysosomal alpha-glucosidase
External Id: CHEMBL2061356

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5-[(1S,3aR,4R,6aR)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]fur-1-yl]-1,3-benzodioxol

5-[(1S,3aR,4R,6aR)-4-(2H-1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2H-1,3-benzodioxole

Sesamolin

5-[(1S,3aR,4R,6aR)-4-(1,3-Benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

(1S,3aR,4R,6aR)-5-[4-(1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

5-[4-(1,3-Benzodioxolol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole

1,3-benzodioxol-5-yl (1R,3aR,4S,6aR)-4-(1,3-benzodioxol-5-yl)perhydrofuro[3,4-c]furan-1-yl ether

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China
Product Name: Sesamolin
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Sesamolin

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