Magnolol

Modify Date: 2024-01-02 17:24:10

Magnolol Structure
Magnolol structure
Common Name Magnolol
CAS Number 528-43-8 Molecular Weight 266.334
Density 1.1±0.1 g/cm3 Boiling Point 401.0±40.0 °C at 760 mmHg
Molecular Formula C18H18O2 Melting Point 99 - 101ºC
MSDS Chinese USA Flash Point 184.5±21.9 °C
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger

 Use of Magnolol


Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.

 Names

Name Magnolol
Synonym More Synonyms

 Magnolol Biological Activity

Description Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively.
Related Catalog
Target

RXRα:10.4 μM (EC50)

PPARγ:17.7 μM (EC50)

In Vitro Magnolol is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 µM and 17.7 µM, respectively. Magnolol (26.2-80 µM) binds to RXRαLBD and PPARγLBD in a dose dependent manner, with Kd values of 45.7 µM and 1.67 µM, respectively. Magnolol (1-20 µM) induces the transcription of PPRE in a dose-dependent manner, but shows no activity on RXRE transcription[1]. Magnolol (1, 3, 10 µM) enhances adipocyte differentiation of both 3T3-L1 pre-adipocystes and C3H10T1/2 pluripotent stem cells in the presence of insulin. Magnolol (10 μM) upregulates mRNA expression of marker genes for adipocyte differentiation. Magnolol (1, 10 μM) shows an increase in basal and insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes[2].
In Vivo Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice[3].
Kinase Assay Binding affinities of magnolol towards purified RXRαLBD and PPARγLBD are analyzed using Biacore 3000 instrument. Proteins are covalently immobilized to CM5 chip using a standard amine-coupling procedure in 10 mM sodium acetate buffer (pH 4.2). The chip is equilibrated with a continuous flow of running buffer (10 mM HEPES, pH 7.4, 150 mM NaCl, 3 mM EDTA, 0.005% (v/v) surfactant P20) for 2 hours. Subsequently, magnolol in a gradient of concentrations are injected into the channels at a flow rate of 20 µL/min for 60 seconds, followed by disassociation for 120 seconds. For the coactivator SRC1 recruitment assays, biotin-labelled SRC1 is immobilized to SA chip. Different concentrations of Magnolol are incubated with 5 µM RXRαLBD or PPARγLBD for 1 hour, and then injected to the channel at a flow rate of 20 µL/min for 60 s, followed by disassociation for 120 s[1].
Cell Assay For differentiation of 3T3-L1 pre-adipocytes, at 2 days after confluence (defined as day 0), cells are incubated in differentiation medium containing 0.5 mM IBMX, 10 μg/mL insulin and 0.25 μM DEX in DMEM containing 10% fetal bovine serum (FBS). After 2 days, the cell culture medium is changed to DMEM containing 10 μg/mL insulin and 10% FBS. The medium is replaced again with fresh DMEM containing 10% FBS after 2 days. Adipocytes are used 6-8 days after the initiation of differentiation. In adipogenesis studies, 3T3-L1 pre-adipocytes and C3H10T1/2 pluripotent stem cells grown in DMEM supplemented with 10% bovine calf serum (day 0) are treated with insulin (1 μg/mL) with/without Magnolol in 10% FBS contained DMEM at the indicated concentration for 9 days. Fresh medium containing insulin (1 μg/mL) and 10% FBS with/without magnolol is replenished every 3 days[2].
Animal Admin Experimental colitis mice model is induced by routine administration of dextran sulfate sodium (DSS) solution dissolved in drinking distilled water at a concentration of 2.0% (w/v) ad libitum for 5 consecutive days. Distilled water is given to mice in the normal group for the same period. The body weight of each mice is recorded daily in the morning (9:00 a.m.). On day 6, the mice with significant body weight loss, diarrhea, and gross bleeding are considered as experimental candidates of colitis. All the mice with comparable disease index are then randomly divided into 5 groups (n = 8/group): (1) DSS model group, intragastric administrated with saline; (2) positive control group, intraperitoneal injected with infliximab (5 mg/kg); (3) low dose treatment group, intragastric administrated with Magnolol (5 mg/kg); (4) medium dose treatment group, intragastric administrated with Magnolol (10 mg/kg); (5) high dose treatment group, intragastric administrated with Magnolol (15 mg/kg). The mice in control group receives drinking water without DSS throughout the entire experimental period and intragastric administrated with saline[3].
References

[1]. Zhang H, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One. 2011;6(11):e28253.

[2]. Choi SS, et al. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14.

[3]. Zhao L, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017 Jul 20;22(7). pii: E1218.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 401.0±40.0 °C at 760 mmHg
Melting Point 99 - 101ºC
Molecular Formula C18H18O2
Molecular Weight 266.334
Flash Point 184.5±21.9 °C
Exact Mass 266.130676
PSA 40.46000
LogP 3.94
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.602
Storage condition 2-8°C

 Safety Information

Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H315-H318-H335-H411
Precautionary Statements P261-P273-P280-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes N:Dangerousfortheenvironment;
Risk Phrases R37/38;R41;R51/53
Safety Phrases S26-S39-S61
RIDADR UN 3077
RTECS DV5105500
Hazard Class 9.0
HS Code 2907299090

 Customs

HS Code 2907299090
Summary 2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

 Articles8

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Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9.

J. Pharm. Sci. 104 , 2369-77, (2015)

In this study, we aimed to determine the glucuronidation potential of psoralidin in humans and to perform validation on use of psoralidin-3-O-glucuronidation as a functional marker for UGT1A9. Glucuro...

Resuscitation from experimental traumatic brain injury by magnolol therapy.

J. Surg. Res. 184(2) , 1045-52, (2013)

The purpose of the present study was to determine whether magnolol, a free radical scavenger, mitigates the deleterious effects of traumatic brain injury (TBI).Traumatic brain injuries were induced in...

Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway.

Cancer Sci. 106 , 1341-50, (2015)

Magnolol, the major active compound found in Magnolia officinalis has a wide range of clinical applications due to its anti-inflammation and anti-oxidation effects. This study investigated the effects...

 Synonyms

[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-
MAGNOLIABARKEXTRACT
DEHYDRODICHAVICOL
Honokiol std.
5,5'-Diallyl-2,2'-biphenyldiol
Magnolol
[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-
1U2R DQ CR BQ E2U1
MFCD00016658
2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol
2,2'-Bichavicol
5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol
5,5'-Diallyl-2,2'-dihydroxybiphenyl
5,5′-Diallyl-2,2′-biphenyldiol
Maglol
5,5'-diallyl-biphenyl-2,2'-diol
2,2'-Dihydroxy-5,5'-diallylbiphenyl
5,5'-Diallylbiphenyl-2,2'-diol
5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol
5,5'-Di(2-propèn-1-yl)-2,2'-biphényldiol
Top Suppliers:I want be here
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  • China
  • Product Name: Magnolol
  • Price: ¥Inquiry/50mg
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Xueping-Zheng





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Price: ¥86.5/5g

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