Acetamide,N-9H-fluoren-2-yl-N-hydroxy

Modify Date: 2026-06-30 14:07:22

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure
Acetamide,N-9H-fluoren-2-yl-N-hydroxy structure
Common Name Acetamide,N-9H-fluoren-2-yl-N-hydroxy
CAS Number 53-95-2 Molecular Weight 239.26900
Density 1.322g/cm3 Boiling Point 455.1ºC at 760mmHg
Molecular Formula C15H13NO2 Melting Point 136 - 137ºC
MSDS N/A Flash Point 229ºC

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name N-hydroxy-2-acetamidofluorene
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.322g/cm3
Boiling Point 455.1ºC at 760mmHg
Melting Point 136 - 137ºC
Molecular Formula C15H13NO2
Molecular Weight 239.26900
Flash Point 229ºC
Exact Mass 239.09500
PSA 40.54000
LogP 2.99990
Index of Refraction 1.696

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AK8575000
CHEMICAL NAME :
Acetohydroxamic acid, N-fluoren-2-yl-
CAS REGISTRY NUMBER :
53-95-2
LAST UPDATED :
199806
DATA ITEMS CITED :
100
MOLECULAR FORMULA :
C15-H13-N-O2
MOLECULAR WEIGHT :
239.29
WISWESSER LINE NOTATION :
L B656 HHJ ENQV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1000 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
120 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
102 mg/kg/3W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2991 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
24 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
27 gm/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - facilitates action of known carcinogen
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
9800 mg/kg/56W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3880 mg/kg/40W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
13 gm/kg/94W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4700 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
8640 mg/kg/32W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
1250 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1075 mg/kg/16W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
142 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
237 mg/kg/4W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
806 mg/kg/12W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
205 mg/kg/7W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2677 mg/kg/32W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
216 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1344 mg/kg/20W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
485 mg/kg/9W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
61 mg/kg/5W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
150 mg/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Micronucleus test
TYPE OF TEST :
Morphological transformation
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA damage
TYPE OF TEST :
DNA damage
TYPE OF TEST :
DNA adduct
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
DNA inhibition
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
DNA damage

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Mammal - dog Cells - not otherwise specified
DOSE/DURATION :
100 nmol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,3974,1982 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950- Volume(issue)/page/year: 13,271,1970 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code 2924299090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~76%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Boege, Nicolas; Krueger, Sarah; Schroeder, Marcus; Meier, Chris Synthesis, 2007 , # 24 p. 3907 - 3914

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Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Huggett, Anthony C.; Cone, James L.; Thorgeirsson, Snorri S.; Roller, Peter P. Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4933 - 4937

~%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Defrancq, Eric; Leterme, Anne; Pelloux, Nadia; Lhomme, Marie-France; Lhomme, Jean Tetrahedron, 1991 , vol. 47, # 30 p. 5725 - 5736

~%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Yost,Y.; Gutmann,H.R. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 2497 - 2499

~0%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Defrancq, Eric; Pelloux, Nadia; Leterme, Anne; Lhomme, Marie-France; Lhomme, Jean Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4817 - 4819

~%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

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Literature: Marhevka, Virginia C.; Ebner, Nancy A.; Sehon, Russell D.; Hanna, Patrick E. Journal of Medicinal Chemistry, 1985 , vol. 28, # 1 p. 18 - 24

~%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

Detail Learn More
Literature: Defrancq, Eric; Pelloux, Nadia; Leterme, Anne; Lhomme, Marie-France; Lhomme, Jean Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 4817 - 4819

~0%

Acetamide,N-9H-fluoren-2-yl-N-hydroxy Structure

Acetamide,N-9H-...

CAS#:53-95-2

Detail Learn More
Literature: Defrancq, Eric; Leterme, Anne; Pelloux, Nadia; Lhomme, Marie-France; Lhomme, Jean Tetrahedron, 1991 , vol. 47, # 30 p. 5725 - 5736

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Acetamide,N-9H-fluoren-2-yl-N-hydroxyBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Ratio of apparent inactivation rate constant to apparent dissociation (binding) rate ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL845375
Name: Compound was tested for carcinogenic activity on breast after various routes administ...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL770584
Name: Major substrate of human cytosolic sulfotransferase SULT1A2
Source: ChEMBL
Target: Sulfotransferase 1A2
External Id: CHEMBL1743315
Name: Major substrate of human cytosolic sulfotransferase SULT1C2
Source: ChEMBL
Target: Sulfotransferase 1C2
External Id: CHEMBL1743307
Name: Rate of methylthio adduct formation catalyzed by partially purified hamster hepatic e...
Source: ChEMBL
Target: Cricetinae
External Id: CHEMBL631781
Name: Major substrate of human cytosolic sulfotransferase SULT1C4
Source: ChEMBL
Target: Sulfotransferase 1C4
External Id: CHEMBL1743308
Name: Inhibition of AHAT-catalyzed transacylation of 4-aminoazobenzene
Source: ChEMBL
Target: N/A
External Id: CHEMBL747006
Name: Compound was tested for carcinogenic activity on ear duct after various routes admini...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL771448
Name: Compound was tested for carcinogenic activity on liver after various routes administr...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL771336
Name: TP_TRANSPORTER: Northern blot in vivo Fischer male rat
Source: ChEMBL
Target: Multidrug resistance protein 1a
External Id: CHEMBL2077093
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

N-Hydroxy-2-faa
Hydroxyacetylaminofluorene
N-Hydroxy-2-acetamidofluorene
Fluorenyl-2-acethydroxamic acid
Acetamide,N-9H-fluoren-2-yl-N-hydroxy
Nohfaa
N-Hydroxy-aaf
N-hydroxy-N-2-fluorenylacetamide
Acetohydroxamic acid,N-fluoren-2-yl
N-(9H-fluoren-2-yl)-N-hydroxyacetamide

 Acetamide,N-9H-fluoren-2-yl-N-hydroxy | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the boiling point of N-hydroxy-2-acetamidofluorene?
A: Boiling point of N-hydroxy-2-acetamidofluorene is 455.1ºC at 760mmHg.
Q: What is the CAS number of N-hydroxy-2-acetamidofluorene?
A: CAS number of N-hydroxy-2-acetamidofluorene is 53-95-2.
Q: What is the melting point of N-hydroxy-2-acetamidofluorene?
A: Melting point of N-hydroxy-2-acetamidofluorene is 136 - 137ºC.
Q: What are the downstream products of N-hydroxy-2-acetamidofluorene?
A: Related downstream products(CAS) of N-hydroxy-2-acetamidofluorene: 21879-09-4;13111-11-0;16808-85-8;6098-44-8;6098-47-1;61144-82-9;61144-84-1.
Q: What is the English name of N-hydroxy-2-acetamidofluorene?
A: The English name of N-hydroxy-2-acetamidofluorene is N-hydroxy-2-acetamidofluorene.
Q: What English synonyms does N-hydroxy-2-acetamidofluorene have?
A: English synonyms of N-hydroxy-2-acetamidofluorene: N-Hydroxy-2-faa, Hydroxyacetylaminofluorene, N-Hydroxy-2-acetamidofluorene, Fluorenyl-2-acethydroxamic acid, Acetamide,N-9H-fluoren-2-yl-N-hydroxy, Nohfaa, N-Hydroxy-aaf, N-hydroxy-N-2-fluorenylacetamide, Acetohydroxamic acid,N-fluoren-2-yl, N-(9H-fluoren-2-yl)-N-hydroxyacetamide.
Q: What is the molecular weight of N-hydroxy-2-acetamidofluorene?
A: Molecular weight of N-hydroxy-2-acetamidofluorene is 239.26900.
Q: What is the LogP of N-hydroxy-2-acetamidofluorene?
A: LogP of N-hydroxy-2-acetamidofluorene is 2.99990.
Q: What is the molecular formula of N-hydroxy-2-acetamidofluorene?
A: Molecular formula of N-hydroxy-2-acetamidofluorene is C15H13NO2.
Q: What is the Chinese name of 53-95-2?
A: Chinese name of 53-95-2 is 53-95-2.

 Acetamide,N-9H-fluoren-2-yl-N-hydroxyfactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.
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