GMQ hydrochloride

Modify Date: 2024-01-02 18:58:36

GMQ hydrochloride Structure
GMQ hydrochloride structure
Common Name GMQ hydrochloride
CAS Number 5361-15-9 Molecular Weight 237.68900
Density N/A Boiling Point N/A
Molecular Formula C10H12ClN5 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of GMQ hydrochloride


GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research[1].

 Names

Name 1-(4-Methyl-2-quinazolinyl)guanidine hydrochloride (1:1)
Synonym More Synonyms

 GMQ hydrochloride Biological Activity

Description GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research[1].
Related Catalog
In Vitro GMQ (1 mM) 在 pH 7.4 的条件下,产生持续向内电流在 CHO 细胞中[1]。 GMQ 在高浓度时阻断 ASIC 孔隙,对 ASIC1a,ASIC1b 和 ASIC3 的 IC50 值分别为 3.24,1.52 和 6.74 mM[1]。
References

[1]. Alijevic O, Kellenberger S. Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem. 2012 Oct 19;287(43):36059-70.  

 Chemical & Physical Properties

Molecular Formula C10H12ClN5
Molecular Weight 237.68900
Exact Mass 237.07800
PSA 87.68000
LogP 2.91860
Storage condition -20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

D-Amphetamine sulfate
2-GUANIDINO-4-METHYLQUINAZOLINE HYDROCHLORIDE