ML 190
Modify Date: 2024-01-13 14:10:28
ML 190 structure
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Common Name | ML 190 | ||
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| CAS Number | 1355244-02-8 | Molecular Weight | 488.58 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H32N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 190ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1]. |
| Name | N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)-2-(1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazin-5(6H)-yl)acetamide |
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| Synonym | More Synonyms |
| Description | ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 120 nM (KOR)[1] EC50: 129 nM (KOR)[1] |
| In Vitro | ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and 88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM[1]. |
| References |
| Molecular Formula | C27H32N6O3 |
|---|---|
| Molecular Weight | 488.58 |
| Exact Mass | 488.25400 |
| PSA | 84.11000 |
| LogP | 2.68850 |
| ML 190 |
| GMQ hydrochloride |