1355244-02-8

1355244-02-8 structure

Name: ML 190
Chemical Name: N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)-2-(1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazin-5(6H)-yl)acetamide
CAS Number: 1355244-02-8
Molecular Formula: C₂₇H₃₂N₆O₃
Molecular Weight: 488.58
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-11-07 07:42:59
Modify Date: 2024-01-13 14:10:28
ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].

Name	N-(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)-2-(1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazin-5(6H)-yl)acetamide
Synonyms	ML 190 GMQ hydrochloride

Description	ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 120 nM (KOR)[1] EC50: 129 nM (KOR)[1]
In Vitro	ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and 88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM[1].
References	[1]. Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3(3):221-236.