Propiverine hydrochloride

Modify Date: 2024-01-04 19:24:44

Propiverine hydrochloride structure	Common Name	Propiverine hydrochloride
	CAS Number	54556-98-8	Molecular Weight	403.942
	Density	N/A	Boiling Point	494.7ºC at 760 mmHg
	Molecular Formula	C₂₃H₃₀ClNO₃	Melting Point	213-216ºC
	MSDS	Chinese USA	Flash Point	253ºC
	Symbol	GHS05, GHS07	Signal Word	Danger

Use of Propiverine hydrochloride

Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].

Name	Propiverine Hydrochloride
Synonym	More Synonyms

Description	Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
In Vitro	Propiverine (10-3000 nM) inhibits the speciﬁc binding of [3H]NMS, with Kis of 339, 193 and 497 nM in the bladder, submaxillary gland and heart of mice respectively[2].
In Vivo	Propiverine (0.5 mg/day; p.o. once daily for 2 weeks) significantly increases UBP and LPP during passive intravesical pressure elevation, and also increases plasma norepinephrine and epinephrine levelsin rats[1]. Propiverine (0.01-1 mg/kg; i.v.) decreases the UBP and totally suppresses the sneeze reflex at the dose of 1 mg/kg in vivo[1]. Animal Model: Female adult Sprague-Dawley rats (250-270 g)[1] Dosage: 5 mg dissolved in distilled water (0.5 mL) Administration: P.o. once daily for 2 weeks Result: Increased urethral baseline pressure (UBP) and leak-point pressure (LPP) significantly. Increased plasma epinephrine and norepinephrine levels. No significant changes were observed in body weight.
References	[1]. Kitta T, et, al. Effects of propiverine hydrochloride, an anticholinergic agent, on urethral continence mechanisms and plasma catecholamine concentration in rats. Int Urogynecol J. 2013 Apr; 24(4): 683-8. [2]. Ito Y, et, al. Muscarinic Receptor Binding and Plasma Drug Concentration after the Oral Administration of Propiverine in Mice. Low Urin Tract Symptoms. 2010 Apr; 2(1):43-9.

Boiling Point	494.7ºC at 760 mmHg
Melting Point	213-216ºC
Molecular Formula	C₂₃H₃₀ClNO₃
Molecular Weight	403.942
Flash Point	253ºC
Exact Mass	403.191437
PSA	38.77000
LogP	4.73410
Storage condition	-20°C Freezer

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH3297000

CHEMICAL NAME :: Acetic acid, diphenylpropoxy-, 1-methyl-4-piperidyl ester, hydrochloride

CAS REGISTRY NUMBER :: 54556-98-8

LAST UPDATED :: 199403

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H29-N-O3.Cl-H

MOLECULAR WEIGHT :: 403.99

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEXXA8 German (East) Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #139212 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/1Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Liver - changes in liver weight Endocrine - changes in pituitary weight

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 15,107,1990 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral Reproductive - Effects on Newborn - physical Reproductive - Effects on Newborn - delayed effects

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 250 mg/kg

SEX/DURATION :: female 17-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 14(Suppl 2),221,1989

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	37/38-41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport
RTECS	AH3297000
HS Code	2933399090

1-Methyl-4-pipe...

CAS#:106-52-5

N/A

CAS#:94686-44-9

Propiverine hyd...

CAS#:54556-98-8

Literature: WO2011/114195 A1, ; Page/Page column 6-7 ;

Precursor 1
CAS#:106-52-5 1-Methyl-4-pipe...
DownStream 1
CAS#:60569-19-9 1-METHYLPIPERID...

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Excitatory effect of propiverine hydrochloride on urethral activity in rats.

Int. J. Urol. 19(6) , 575-82, (2012)

To investigate the effects of the antimuscarinic agent, propiverine, on the bladder and urethra in rats.A total of 54 female rats were given propiverine, imidafenacin (an antimuscarinic agent), or dis...

[Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy].

Hinyokika Kiyo. 57(2) , 71-6, (2011)

The efficacy and safety of additional administration of propiverine were prospectively studied for naftopidil-resistant nocturia in patients with benign prostatic hypertrophy (BPH). Patients of 50 yea...

An overview on mixed action drugs for the treatment of overactive bladder and detrusor overactivity.

Urol. Int. 89(3) , 259-69, (2012)

To provide an overview on the efficacy, tolerability, safety and health-related quality of life (HRQoL) of drugs with a mixed action used in the treatment of overactive bladder (OAB).MEDLINE database ...

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DC Chemicals Limited
China
Product Name: Propiverine HCl
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Propiverine hydrochloride
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Propiverine hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Propiverine Hydrochloride
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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