Acetohydroxamic acid

Modify Date: 2024-01-02 20:22:33

Acetohydroxamic acid structure	Common Name	Acetohydroxamic acid
	CAS Number	546-88-3	Molecular Weight	75.067
	Density	1.2±0.1 g/cm3	Boiling Point	231.4ºC at 760 mmHg
	Molecular Formula	C₂H₅NO₂	Melting Point	88-90 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Danger

Use of Acetohydroxamic acid

Acetohydroxamic acid is a potent and irreversible inhibitor of bacterial and plant urease and also used as adjunctive therapy in chronic urinary infection.Target: UreaseAcetohydroxamic acid selectively inhibits arachidonate 5-lipoxygenase and thus has potential use in the treatment of asthma.

Name	acetohydroxamic acid
Synonym	More Synonyms

Description	Acetohydroxamic acid is a potent and irreversible inhibitor of bacterial and plant urease and also used as adjunctive therapy in chronic urinary infection.Target: UreaseAcetohydroxamic acid selectively inhibits arachidonate 5-lipoxygenase and thus has potential use in the treatment of asthma.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection
References	[1]. Sharma M, et al. Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225. Indian J Microbiol. 2012 Mar;52(1):76-82.

Density	1.2±0.1 g/cm3
Boiling Point	231.4ºC at 760 mmHg
Melting Point	88-90 °C(lit.)
Molecular Formula	C₂H₅NO₂
Molecular Weight	75.067
Exact Mass	75.032028
PSA	49.33000
LogP	-1.59
Index of Refraction	1.421
Stability	Moisture and Temperature Sensitive

Acetohydroxamic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AK8157000

CHEMICAL NAME :: Acetohydroxamic acid

CAS REGISTRY NUMBER :: 546-88-3

LAST UPDATED :: 199410

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C2-H5-N-O2

MOLECULAR WEIGHT :: 75.08

WISWESSER LINE NOTATION :: QMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 750 mg/kg

SEX/DURATION :: female 12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 20 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 152,225,1985

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H360
Precautionary Statements	P201-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R61
Safety Phrases	S53-S45
RIDADR	3263
WGK Germany	3
RTECS	AK8157000
Packaging Group	II
HS Code	2942000000

Precursor 10
CAS#:108-24-7 Ethanoic anhydride CAS#:60-35-5 Acetamide CAS#:141-78-6 ethyl acetate CAS#:542-10-9 1,1-Ethanediol ...
CAS#:127-09-3 Sodium acetate CAS#:463-51-4 ketene CAS#:75-36-5 Acetyl chloride CAS#:79-24-3 Nitroethane
CAS#:2597-54-8 ACETYLURETHANE CAS#:869669-06-7 hydroxylamine s...
DownStream 10
CAS#:455280-00-9 5-Bromobenzo[d]... CAS#:36216-80-5 Benzo[d]isoxazo... CAS#:14181-72-7 2-bromo-1-pheny... CAS#:177995-39-0 6-Bromobenzo[d]...
CAS#:1956-40-7 (NZ)-N-(1-napht... CAS#:1956-45-2 Methyl 2-thieny... CAS#:1837-71-4 2,4-dimethyl-4H... CAS#:2302-87-6 Acetic acid,2-(...
CAS#:79-16-3 N-Methylacetamide CAS#:588-46-5 n-benzylacetamide

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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