3-Hydroxyanthranilic acid

Modify Date: 2024-01-03 12:15:26

3-Hydroxyanthranilic acid structure	Common Name	3-Hydroxyanthranilic acid
	CAS Number	548-93-6	Molecular Weight	153.135
	Density	1.5±0.1 g/cm3	Boiling Point	356.9±37.0 °C at 760 mmHg
	Molecular Formula	C₇H₇NO₃	Melting Point	240 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	169.6±26.5 °C
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of 3-Hydroxyanthranilic acid

3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.

Name	3-hydroxyanthranilic acid
Synonym	More Synonyms

Description	3-Hydroxyanthranilic acid is a tryptophan metabolite in the kynurenine pathway.
Related Catalog	Natural Products >> Acids and Aldehydes Research Areas >> Others
Target	Human Endogenous Metabolite
References	[1]. Lee WS, et al. The tryptophan metabolite 3-hydroxyanthranilic acid suppresses T cell responses by inhibiting dendritic cell activation. Int Immunopharmacol. 2013 Nov;17(3):721-6.

Density	1.5±0.1 g/cm3
Boiling Point	356.9±37.0 °C at 760 mmHg
Melting Point	240 °C (dec.)(lit.)
Molecular Formula	C₇H₇NO₃
Molecular Weight	153.135
Flash Point	169.6±26.5 °C
Exact Mass	153.042587
PSA	83.55000
LogP	1.05
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.691
Storage condition	−20°C

3-Hydroxyanthranilic acid MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG2625000

CHEMICAL NAME :: Benzoic acid, 2-amino-3-hydroxy-

CAS REGISTRY NUMBER :: 548-93-6

BEILSTEIN REFERENCE NO. :: 0973356

LAST UPDATED :: 199612

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C7-H7-N-O3

MOLECULAR WEIGHT :: 153.15

WISWESSER LINE NOTATION :: ZR BQ FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg female 13-17 day(s) after conception

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis Lungs, Thorax, or Respiration - bronchiogenic carcinoma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors Endocrine - adrenal cortex tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg/19W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2040 mg/kg/59W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 121 mg/kg/21D-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - bronchiogenic carcinoma Liver - tumors

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Primate - monkey Kidney

DOSE/DURATION :: 100 mg/L

REFERENCE :: TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959- Volume(issue)/page/year: 15,1505,1973 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302 + H312 + H332-H315-H319-H335-H351
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38-40
Safety Phrases	S22-S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DG2625000
HS Code	2922509090

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HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.

Biosci. Biotechnol. Biochem. 77(2) , 295-300, (2013)

Valproic acid (VPA) is a short-chained, branched fatty acid that is widely used in humans as an anticonvulsant and mood stabilizer, and has been reported to increase the liver NAD concentration. We in...

Time-dependent effects of L-tryptophan administration on urinary excretion of L-tryptophan metabolites.

J. Nutr. Sci. Vitaminol. 60(4) , 255-60, (2014)

We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy wome...

The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.

J. Nutr. 143(7) , 1046-51, (2013)

In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxyg...

Acid, 3-Hydroxyanthranilic

MFCD00007700

3-hydroxy-Anthranilic acid

Anthranilic acid, 3-hydroxy-

3-Hydroxy-2-aminobenzoic acid

3-OH-anthranilic acid

EINECS 208-962-5

Benzoic acid, 2-amino-3-hydroxy-

2-Amino-3-hydroxybenzoic acid

3-Hydroxy-2-aminobenzoate

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 3-Hydroxyanthranilic acid
Price: ￥318.0/250mg ￥758.0/1g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzoic acid,2-amino-3-hydroxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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3-Hydroxyanthranilic acid

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