6-Maleimidocapronic acid
6-Maleimidocapronic acid structure
|
Common Name | 6-Maleimidocapronic acid | ||
|---|---|---|---|---|
| CAS Number | 55750-53-3 | Molecular Weight | 211.214 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 407.3±28.0 °C at 760 mmHg | |
| Molecular Formula | C10H13NO4 | Melting Point | 86-91ºC | |
| MSDS | Chinese USA | Flash Point | 200.1±24.0 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of 6-Maleimidocapronic acid6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-Maleimidocaproic Acid |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 6-Maleimidocapronic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl-Chain |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 407.3±28.0 °C at 760 mmHg |
| Melting Point | 86-91ºC |
| Molecular Formula | C10H13NO4 |
| Molecular Weight | 211.214 |
| Flash Point | 200.1±24.0 °C |
| Exact Mass | 211.084457 |
| PSA | 74.68000 |
| LogP | 0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.537 |
| InChIKey | WOJKKJKETHYEAC-UHFFFAOYSA-N |
| SMILES | O=C(O)CCCCCN1C(=O)C=CC1=O |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~71%
6-Maleimidocapr... CAS#:55750-53-3 |
| Literature: Dalton Transactions, , # 24 p. 3886 - 3897 |
|
~74%
6-Maleimidocapr... CAS#:55750-53-3 |
| Literature: Journal of Medicinal Chemistry, , vol. 56, # 24 p. 9955 - 9968 |
|
~30%
6-Maleimidocapr... CAS#:55750-53-3 |
| Literature: EP665020 A3, ; |
|
~%
6-Maleimidocapr... CAS#:55750-53-3
Learn More
|
| Literature: US8241655 B2, ; |
|
~%
6-Maleimidocapr... CAS#:55750-53-3 |
| Literature: Dalton Transactions, , # 24 p. 3886 - 3897 |
![6-[[(2Z)-3-carboxy-1-oxo-2-propenyl]amino]hexanoic acid structure](https://image.chemsrc.com/caspic/263/57079-14-8.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 4 | |
CAS#:55750-63-5
CAS#:57-13-6
CAS#:157503-18-9
CAS#:82333-93-5This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
|
An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors.
Anal. Bioanal. Chem 407(2) , 387-96, (2015) A strength of microfluidic chip laboratories is the rapid heat transfer that, in principle, enables a very homogeneous temperature distribution in chemical processes. In order to exploit this potentia... |
|
|
Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport.
Exp. Cell Res. 338 , 251-60, (2015) Cellular levels of inhibitor of apoptosis (IAP) proteins are elevated in multiple human cancers and their activities often play a part in promoting cancer cell survival by blocking apoptotic pathways,... |
|
|
Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia.
Can. J. Physiol. Pharmacol. 92(12) , 1037-43, (2014) Insulin resistance, a key feature of obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM), results in a variety of metabolic and vascular abnormalities. Metabolic disturbances associated w... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
|
Name: Inhibitory activity against Prostaglandin G/H synthase
Source: ChEMBL
Target: Prostaglandin G/H synthase 1
External Id: CHEMBL763068
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid |
| MFCD00043140 |
| 6-(2,5-dioxopyrrol-1-yl)hexanoic acid |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the storage conditions for 6-Maleimidocaproic Acid? |
| A: Storage conditions for 6-Maleimidocaproic Acid: 2-8°C. |
| Q: What English synonyms does 6-Maleimidocaproic Acid have? |
| A: English synonyms of 6-Maleimidocaproic Acid: 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoic acid, MFCD00043140, 6-(2,5-dioxopyrrol-1-yl)hexanoic acid. |
| Q: What is the safety information for 6-Maleimidocaproic Acid? |
| A: Safety information for 6-Maleimidocaproic Acid: S26-S36. |
| Q: What is the melting point of 6-Maleimidocaproic Acid? |
| A: Melting point of 6-Maleimidocaproic Acid is 86-91ºC. |
| Q: What are the downstream products of 6-Maleimidocaproic Acid? |
| A: Related downstream products(CAS) of 6-Maleimidocaproic Acid: 55750-63-5;57-13-6;157503-18-9;82333-93-5. |
| Q: What is the boiling point of 6-Maleimidocaproic Acid? |
| A: Boiling point of 6-Maleimidocaproic Acid is 407.3±28.0 °C at 760 mmHg. |
| Q: What is the English name of 6-Maleimidocaproic Acid? |
| A: The English name of 6-Maleimidocaproic Acid is 6-Maleimidocaproic Acid. |
| Q: What is the molecular formula of 6-Maleimidocaproic Acid? |
| A: Molecular formula of 6-Maleimidocaproic Acid is C10H13NO4. |
| Q: What is the CAS number of 6-Maleimidocaproic Acid? |
| A: CAS number of 6-Maleimidocaproic Acid is 55750-53-3. |
| Q: What is the SMILES notation of 6-Maleimidocaproic Acid? |
| A: SMILES notation of 6-Maleimidocaproic Acid is O=C(O)CCCCCN1C(=O)C=CC1=O. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |