Galloflavin

Modify Date: 2024-01-07 18:52:07

Galloflavin Structure
Galloflavin structure
 Common Name Galloflavin
CAS Number 568-80-9 Molecular Weight 278.17100
Density 2.1g/cm3 Boiling Point 159.8ºC at 760 mmHg
Molecular Formula C12H6O8 Melting Point N/A
MSDS Chinese USA Flash Point 37.4ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Galloflavin


Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].

 Names

Name Galloflavin
Synonym More Synonyms

 Galloflavin Biological Activity

Description Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 µM (LDH-A) and 15.06 µM (LDH-B). Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].
Related Catalog
In Vitro Galloflavin effectively inhibits cell growth in endometrial cancer cell lines and primary cultures of human endometrial cancer through its involvement in multiple signaling pathways that regulate metabolism, cell cycle, apoptosis, cell stress and metastasis[3].
References

[1]. Manerba M, Vettraino M, Fiume L, et al. Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem. 2012;7(2):311-317.

[2]. Farabegoli F, et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci. 2012;47(4):729-738.

[3]. Han X, et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 2015;8:2. Published 2015 Jan 29.

 Chemical & Physical Properties

Density 2.1g/cm3
Boiling Point 159.8ºC at 760 mmHg
Molecular Formula C12H6O8
Molecular Weight 278.17100
Flash Point 37.4ºC
Exact Mass 278.00600
PSA 141.34000
LogP 0.72180
Index of Refraction 1.848

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
RIDADR NONH for all modes of transport
HS Code 2932999099

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3,8,9,10-tetrahydroxypyrano[3,2-c]isochromene-2,6-dione
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Related Compounds: More...
Galloflavin
76896-80-5
Galloflavin Potassium
1780260-20-9
Chemsrc provides Galloflavin(CAS#:568-80-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Galloflavin are included as well.>> amp version: Galloflavin

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