Nauclefine
Modify Date: 2025-08-25 16:24:06
Nauclefine structure
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Common Name | Nauclefine | ||
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| CAS Number | 57103-51-2 | Molecular Weight | 287.31500 | |
| Density | 1.46g/cm3 | Boiling Point | 616.8ºC at 760 mmHg | |
| Molecular Formula | C18H13N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 326.8ºC | |
Use of NauclefineNauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1]. |
| Name | parvine |
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| Synonym | More Synonyms |
| Description | Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway[1]. |
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| Related Catalog | |
| In Vitro | Nauclefine (250 nM, 48 h) 可以抑制 HeLa 细胞活力，并诱导细胞凋亡，造成细胞 PDE3A 和 SLFN12 依赖性死亡。Nauclefine 可以结合 PDE3A，但不抑制其磷酸二酯酶活性，能够促进 PDE3A 和 SLFN12 之间的相互作用，并通过增加 SLFN12 的稳定性促进细胞死亡[1]。 |
| In Vivo | Nauclefine (5 mg/kg, intratumorally, once per day for 22 days) 在感染 HeLa 细胞的雌性裸鼠(Balb/c-nu)中，显著降低了HeLa-luc 细胞肿瘤的总体生长，特别是治疗第 6 天后肿瘤体积明显减小，且没有导致小鼠体重的任何降低。其对肿瘤生长的抑制依赖于 PDE3A 和 SLFN12 的表达[1]。 |
| References |
| Density | 1.46g/cm3 |
|---|---|
| Boiling Point | 616.8ºC at 760 mmHg |
| Molecular Formula | C18H13N3O |
| Molecular Weight | 287.31500 |
| Flash Point | 326.8ºC |
| Exact Mass | 287.10600 |
| PSA | 50.68000 |
| LogP | 3.10090 |
| Index of Refraction | 1.793 |
| InChIKey | BGFQUYBVDVRJSP-UHFFFAOYSA-N |
| SMILES | O=c1c2cnccc2cc2n1CCc1c-2[nH]c2ccccc12 |
| HS Code | 2933990090 |
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CAS#:89651-72-9| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| 8,13-Dihydroindolo[2',3':3,4]pyrido[1,2-b][2,7]naphthyridin-5(7H)-one |
| 8,13-dihydro-7H-indolo[2',3':3,4]pyrido[1,2-b][2,7]naphthyridin-5-one |