7-Hydroxy-4-(trifluoromethyl)coumarin

Modify Date: 2025-08-27 08:47:50

7-Hydroxy-4-(trifluoromethyl)coumarin structure	Common Name	7-Hydroxy-4-(trifluoromethyl)coumarin
	CAS Number	575-03-1	Molecular Weight	230.140
	Density	1.6±0.1 g/cm3	Boiling Point	311.4±42.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₅F₃O₃	Melting Point	178-180 °C(lit.)
	MSDS	Chinese USA	Flash Point	142.2±27.9 °C
	Symbol	GHS06	Signal Word	Danger

Use of 7-Hydroxy-4-(trifluoromethyl)coumarin

4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes[1].

Name	7-Hydroxy-4-(trifluoromethyl)coumarin
Synonym	More Synonyms

Description	4-(Trifluoromethyl)umbelliferone is fluorescent probe substrate for rat hepatic cytochrome P450 enzymes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Others
References	[1]. Renwick AB, et, al. Evaluation of 7-benzyloxy-4-trifluoromethylcoumarin, some other 7-hydroxy-4-trifluoromethylcoumarin derivatives and 7-benzyloxyquinoline as fluorescent substrates for rat hepatic cytochrome P450 enzymes. Xenobiotica. 2001 Dec;31(12):861-78.

Density	1.6±0.1 g/cm3
Boiling Point	311.4±42.0 °C at 760 mmHg
Melting Point	178-180 °C(lit.)
Molecular Formula	C₁₀H₅F₃O₃
Molecular Weight	230.140
Flash Point	142.2±27.9 °C
Exact Mass	230.019073
PSA	50.44000
LogP	2.88
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.546
InChIKey	CCKWMCUOHJAVOL-UHFFFAOYSA-N
SMILES	O=c1cc(C(F)(F)F)c2ccc(O)cc2o1
Water Solubility	DMF: soluble

7-Hydroxy-4-(trifluoromethyl)coumarin MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300-H315-H319-H335
Precautionary Statements	P261-P264-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S36-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
HS Code	2932209090

Ethyl trifluoro...

CAS#:372-31-6

Resorcine

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~99%

7-Hydroxy-4-(tr...

CAS#:575-03-1

Literature: Wu, Jie; Diao, Tianning; Sun, Wei; Li, Yizhe Synthetic Communications, 2006 , vol. 36, # 20 p. 2949 - 2956

Ethyl 5,5,5-tri...

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Resorcine

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7-Benzyloxy-4-(...

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7-Methoxy-4-(tr...

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7-Hydroxy-4-(tr...

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2,4-dibromo-6-(...

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7-Hydroxy-4-(tr...

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DDAO

CAS#:118290-05-4

Literature: Angewandte Chemie - International Edition, , vol. 51, # 37 p. 9344 - 9347 Angew. Chem., , vol. 124, # 37 p. 9478 - 9481,5

Precursor 6
CAS#:372-31-6 Ethyl trifluoro... CAS#:108-46-3 Resorcine CAS#:70961-05-6 Ethyl 5,5,5-tri... CAS#:220001-53-6 7-Benzyloxy-4-(...
CAS#:575-04-2 7-Methoxy-4-(tr... CAS#:1407499-96-0 2,4-dibromo-6-(...
DownStream 3
CAS#:220001-53-6 7-Benzyloxy-4-(... CAS#:195210-09-4 4-Trifluorometh... CAS#:575-04-2 7-Methoxy-4-(tr...

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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MFCD00037578