promazine

Modify Date: 2026-07-16 21:21:17

promazine structure	Common Name	promazine
	CAS Number	58-40-2	Molecular Weight	284.41900
	Density	1.133g/cm3	Boiling Point	412.7ºC at 760mmHg
	Molecular Formula	C₁₇H₂₀N₂S	Melting Point	25°C
	MSDS	N/A	Flash Point	203.4ºC

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	promazine
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.133g/cm3
Boiling Point	412.7ºC at 760mmHg
Melting Point	25°C
Molecular Formula	C₁₇H₂₀N₂S
Molecular Weight	284.41900
Flash Point	203.4ºC
Exact Mass	284.13500
PSA	31.78000
LogP	4.30600
Index of Refraction	1.6000 (estimate)
InChIKey	ZGUGWUXLJSTTMA-UHFFFAOYSA-N
SMILES	CN(C)CCCN1c2ccccc2Sc2ccccc21

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO7000000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 58-40-2

LAST UPDATED :: 199706

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C17-H20-N2-S

MOLECULAR WEIGHT :: 284.45

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,507,1958

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 192 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14500 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - changes in circulation Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 119,311,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 401 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic)

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 155,69,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1798,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Behavioral - sleep

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 19,87,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 1-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: JNEUAY Journal of Neuropsychiatry. (Chicago, IL) V.1-5, 1959-64. For publisher information, see BENPBG. Volume(issue)/page/year: 3,295,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 4 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 12,346,1961 *** REVIEWS *** TOXICOLOGY REVIEW IDPYAK Industrial Pharmacology. (Mount Kisco, NY) V.1-3, 1974-79. Discontinued. Volume(issue)/page/year: 1,203,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6079 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 10
CAS#:583-55-1 1-Bromo-2-iodob... CAS#:6320-02-1 2-Bromothiophenol CAS#:109-55-7 3-Dimethylamino... CAS#:583-53-9 1,2-Dibromobenzene
CAS#:92-84-2 Phenothiazine CAS#:109-54-6 3-Chloro-N,N-di... CAS#:50-53-3 Chlorpromazine CAS#:69-09-0 Chlorpromazine ...
CAS#:3179-63-3 3-Dimethylamino... CAS#:18956-87-1 10H-Phenothiazi...
DownStream 7
CAS#:38076-67-4 PHENOTHIAZINE-1... CAS#:92-84-2 Phenothiazine CAS#:2095-20-7 desmonomethylpr... CAS#:68-12-2 N,N-Dimethylfor...
CAS#:581-30-6 3-Phenothiazone CAS#:1207-71-2 10H-Phenothiazi... CAS#:146-21-4 Promazine 5-sul...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Dissociation constant was reported
Source: ChEMBL
Target: N/A
External Id: CHEMBL632402

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Effective permeability across porcine polar brain lipid after 4 hrs by PAMPA
Source: ChEMBL
Target: N/A
External Id: CHEMBL2025124

Name: pKa (acid-base dissociation constant) as determined by Luan ref: Pharm. Res. 2005
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449009

Name: Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae MKPDR...
Source: ChEMBL
Target: Pleiotropic ABC efflux transporter of multiple drugs
External Id: CHEMBL1696307

Name: Apparent partition coefficient was measured as histamine releasing activity in rat ma...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL797214

Name: Permeability of the compound by PAMPA assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL3859148

Name: Permeability of the compound at 25 ug/ml at 7.4 pH after 18 hrs by PAMPA
Source: ChEMBL
Target: N/A
External Id: CHEMBL3859151

Name: Effective permeability of the compound at 100 ug/ml after 10 hrs by BBB-PAMPA method
Source: ChEMBL
Target: N/A
External Id: CHEMBL4422901

Name: Effective permeability of the compound by BBB-PAMPA method
Source: ChEMBL
Target: N/A
External Id: CHEMBL4422943

Total 462, Current Page 1 of 47

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Ampazine

Promazin

Sinophenin

Liranol

N,N-dimethyl-10H-phenothiazine-10-propanamine

Protactyl

Esparin

EINECS 200-382-0

Berophen

N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine

Promazina

Prazine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does promazine have?

A: English synonyms of promazine: Ampazine, Promazin, Sinophenin, Liranol, N,N-dimethyl-10H-phenothiazine-10-propanamine, Protactyl, Esparin, EINECS 200-382-0, Berophen, N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine, Promazina, Prazine.

Q: What is the English name of promazine?

A: The English name of promazine is promazine.

Q: What is the CAS number of promazine?

A: CAS number of promazine is 58-40-2.

Q: What is the boiling point of promazine?

A: Boiling point of promazine is 412.7ºC at 760mmHg.

Q: What are the downstream products of promazine?

A: Related downstream products(CAS) of promazine: 38076-67-4;92-84-2;2095-20-7;68-12-2;581-30-6;1207-71-2;146-21-4.

Q: What is the SMILES notation of promazine?

A: SMILES notation of promazine is CN(C)CCCN1c2ccccc2Sc2ccccc21.

Q: What is the molecular formula of promazine?

A: Molecular formula of promazine is C17H20N2S.

Q: What is the molecular weight of promazine?

A: Molecular weight of promazine is 284.41900.

Q: What is the polar surface area (PSA) of promazine?

A: Polar surface area (PSA) of promazine is 31.78000.

Q: What is the LogP of promazine?

A: LogP of promazine is 4.30600.

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promazine

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HEALTH HAZARD DATA

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Precursor & DownStream

promazineBioassay

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promazine | FAQ

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.