[Met5]enkephalin amide

Modify Date: 2024-01-02 17:19:40

[Met5]enkephalin amide Structure
[Met5]enkephalin amide structure
Common Name [Met5]enkephalin amide
CAS Number 60117-17-1 Molecular Weight 572.67600
Density N/A Boiling Point N/A
Molecular Formula C27H36N6O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [Met5]enkephalin amide


[Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.

 Names

Name [Met5]enkephalin amide
Synonym More Synonyms

 [Met5]enkephalin amide Biological Activity

Description [Met5]-Enkephalin, amide is an agonist for δ opioid receptors as well as putative ζ (zeta) opioid receptors.
Related Catalog
Target

δ and ζ opioid receptor[1]

In Vitro [Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine[2].
References

[1]. Stiene-Martin A, et al. Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro. J Neurosci Res. 1991 Aug;29(4):538-48.

[2]. Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8.

 Chemical & Physical Properties

Molecular Formula C27H36N6O6S
Molecular Weight 572.67600
Exact Mass 572.24200
PSA 231.04000
LogP 1.90930

 Synonyms

YGGFM-NH2
[Met-NH2]5-enkephalin
(Met5)-enkephalinamide
Met5-enkephallin amide
methionine enkephalinamide
Met-enkephalin amide
[MET5]-ENKEPHALIN AMIDE
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