Metallo-β-lactamase-IN-7

Modify Date: 2025-08-25 19:21:40

Metallo-β-lactamase-IN-7 structure	Common Name	Metallo-β-lactamase-IN-7
	CAS Number	2752453-58-8	Molecular Weight	274.30
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₀N₄O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Metallo-β-lactamase-IN-7

Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains[1].

Name	Metallo-β-lactamase-IN-7

Description	Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 0.019 μM (VIM-2), 13.64 μM (VIM-1), 0.38 μM (VIM-5)[1]
In Vitro	Metallo-β-lactamase-IN-7 (compound 59) (10 μM; 18 - 20 hours) can potentiate Meropenem activity against VIM-2 mediated antibacterial resistance with FIC index values of 0.02[1]. Metallo-β-lactamase-IN-7 (100 μM) potentiates the antibacterial activity of Meropenem against PA W35 with FIC index values of 0.125[1].
References	[1]. Yan YH, Li W, Chen W, et al. Structure-guided optimization of 1H-imidazole-2-carboxylic acid derivatives affording potent VIM-Type metallo-β-lactamase inhibitors. Eur J Med Chem. 2022;228:113965.

Molecular Formula	C₁₂H₁₀N₄O₂S
Molecular Weight	274.30

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Metallo-β-lactamase-IN-7

Use of Metallo-β-lactamase-IN-7

Names

Metallo-β-lactamase-IN-7 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.