Methyl-PEG4-acyl chloride

Modify Date: 2024-01-10 23:27:32

Methyl-PEG4-acyl chloride Structure
Methyl-PEG4-acyl chloride structure
Common Name Methyl-PEG4-acyl chloride
CAS Number 62124-69-0 Molecular Weight 270.70700
Density N/A Boiling Point N/A
Molecular Formula C10H19ClO6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methyl-PEG4-acyl chloride


Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonochloridate
Synonym More Synonyms

 Methyl-PEG4-acyl chloride Biological Activity

Description Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H19ClO6
Molecular Weight 270.70700
Exact Mass 270.08700
PSA 63.22000
LogP 1.05800

 Synonyms

tetraethylene glycol monomethyl ether chloroformate
Carbonochloridic acid,3,6,9,12-tetraoxatridec-1-yl ester
2-{2-[2-(2-methoxyethoxy)-ethoxy]ethoxy}ethyl chloroformate
Methyl-PEG4-acyl chloride
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