BC-23

更新时间：2025-09-18 09:49:38

BC-23结构式	常用名	BC-23	英文名	BC-23
	CAS号	6298-15-3	分子量	439.87
	密度	1.56g/cm3	沸点	615.9ºC at 760mmHg
	分子式	C₂₁H₁₄ClN₃O₄S	熔点	N/A
	MSDS	N/A	闪点	326.3ºC

BC-23用途

BC-23(NSC 45382)是一种蛋白酶体抑制剂。BC-23对蛋白酶体的CT-L活性表现出良好的抑制作用,并且对恶性细胞比正常细胞具有选择性[1][2]。

英文名	3--2-chlor-1.4-naphthochinon

描述	BC-23(NSC 45382)是一种蛋白酶体抑制剂。BC-23对蛋白酶体的CT-L活性表现出良好的抑制作用,并且对恶性细胞比正常细胞具有选择性[1][2]。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体
参考文献	[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. [2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407.

描述

BC-23(NSC 45382)是一种蛋白酶体抑制剂。BC-23对蛋白酶体的CT-L活性表现出良好的抑制作用,并且对恶性细胞比正常细胞具有选择性[1][2]。

相关类别

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 蛋白酶体

参考文献

[1]. Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92.

[2]. Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407.

密度	1.56g/cm3
沸点	615.9ºC at 760mmHg
分子式	C₂₁H₁₄ClN₃O₄S
分子量	439.87
闪点	326.3ºC
精确质量	439.03900
PSA	113.61000
LogP	5.05070
InChIKey	QRPKNPKHGNUFGK-UHFFFAOYSA-N
SMILES	O=C1C(Cl)=C(Nc2ccc(S(=O)(=O)Nc3ccccn3)cc2)C(=O)c2ccccc21
折射率	1.721

2,3-二氯-1,4-萘醌

117-80-6

磺胺吡啶

144-83-2

~53%

BC-23

6298-15-3

文献：Lawrence, Harshani R.; Kazi, Aslamuzzaman; Luo, Yunting; Kendig, Robert; Ge, Yiyu; Jain, Sanjula; Daniel, Kenyon; Santiago, Daniel; Guida, Wayne C.; Sebti, Said M. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 15 p. 5576 - 5592

2,3-二氯-1,4-萘醌

117-80-6

磺胺吡啶

144-83-2

N,N-二乙基苯胺

91-66-7

BC-23

6298-15-3

文献：Calandra; Adams Journal of the American Chemical Society, 1950 , vol. 72, p. 4804

BC-23上游产品 3
CAS号117-80-6 2,3-二氯-1,4-萘醌 CAS号144-83-2 磺胺吡啶 CAS号91-66-7 N,N-二乙基苯胺
BC-23下游产品 0

实验名称：Assays to identify small molecules inhibitory for eIF4E expression
来源：13133
靶标：N/A
External Id：20160513eIF4E

实验名称：Inhibition of PGPH activity of rabbit 26S proteasome
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1219962

实验名称：Inhibition of trypsin like proteolytic activity of rabbit 26S proteasome
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1219961

实验名称：Inhibition of chymotrypsin like proteolytic activity of rabbit 26S proteasome
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1219960

实验名称：Inhibition of proteasome in human HeLa-GFP cells at 10 ug/ml
来源：ChEMBL
靶标：N/A
External Id：CHEMBL2020880

实验名称：Inhibition of caspase-like activity 20S proteasome beta subunit 1 of human MCF7 cells...
来源：ChEMBL
靶标：Proteasome subunit beta type-1
External Id：CHEMBL4711756

实验名称：Inhibition of trypsin-like activity 20S proteasome beta subunit 2 of human MCF7 cells...
来源：ChEMBL
靶标：Proteasome subunit beta type-2
External Id：CHEMBL4711757

实验名称：Increase in K48-linked polyubiquitinated protein expression in human MCF7 cells at IC...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4711762

实验名称：Effect on 20S proteasome beta subunit 5 expression in human MCF7 cells at IC50 after ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4711761

实验名称：Antiproliferative activity against human A549 cells
来源：ChEMBL
靶标：A549
External Id：CHEMBL2020872

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